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Article Abstract
To quantitatively assess lateral geniculate nucleus (LGN) volume using 7 Tesla MRI in patients with Stargardt disease (STGD). A total of 18 patients with STGD and 15 healthy volunteers were examined with a 7 Tesla MRI of the brain. Measures of LGN volume were performed manually by three independent investigators (radiologists) using ITK-SNAP software, version 4.0.0-rc.2. The volume of the thalamus was evaluated using the open-source automated software package FreeSurfer. Before 7 Tesla MRI, patients underwent ophthalmic examination and 1.5 Tesla MRI. The average LGN volume in both hemispheres was significantly smaller in patients with STGD (right, -111.2 mm; left, 107.4 mm) than in the control group (right, -128.7 mm; left, 123.6 mm, respectively) ( < 0.0001). The ratio of LGN to thalamus in the right hemisphere was significantly lower ( = 0.024) in the group of patients with STGD (0.014) than in the control group (0.017). The right and left LGN volumes in MR 7T imaging, as well as the right LGN/thalamus ratio, were reduced in patients with STGD compared to controls. 7T MRI using the 3D MT-weighted SILENT protocol provides new insight into structural changes in the brain in retinal dystrophies and offers a possible marker of the response to future therapies in STGD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12386881 | PMC |
| http://dx.doi.org/10.3390/jcm14165666 | DOI Listing |
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