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L. 'Biloxi' is a cultivated blueberry variety valued for its rich content of phenolic compounds, which contribute to its strong antioxidant activity and recognized health benefits. There is little information on the effects of GA and BA on blueberry, especially when used in combination. This study aimed to evaluate whether GA and BA alter the yield and quality of 'Biloxi' fruits. The experiment included 12 treatments consisting of GA (25, 50 and 100 mg L) and BA concentrations (50 and 100 mg L) alone and combined and a control. The following parameters were analyzed: yield (g) and number of fruits per plant, mass, diameter, pH, soluble solids (SS), titratable acidity (TA), soluble sugars, total phenols, flavonoids, anthocyanins and antioxidant activity. The results indicate that foliar GA and BA application improved the antioxidant capacity and biochemical composition of fruits, without negatively affecting production traits such as yield, fruit size or maturation period. The increases in antioxidant activity, phenol metabolites (total phenols, anthocyanins and flavonoids), soluble sugars, SS and SS/TA ratio were higher with the combination of GA and BA at 100 mg L. These results suggest that the combination of GA and BA is a promising approach to sustainably improve fruit quality in commercial blueberry cultivation, providing both economic and nutritional benefits.
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http://dx.doi.org/10.3390/ijms26167984 | DOI Listing |
ESC Heart Fail
September 2025
Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy.
Heart failure (HF) is a multifactorial and pathophysiological complex syndrome, involving not only neurohormonal activation but also oxidative stress, chronic low-grade inflammation, and metabolic derangements. Central to the cellular defence against oxidative damage is nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that orchestrates antioxidant and cytoprotective responses. Preclinical in vitro and in vivo studies reveal that Nrf2 signalling is consistently impaired in HF, contributing to the progression of myocardial dysfunction.
View Article and Find Full Text PDFToxicol Mech Methods
September 2025
Lung Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
Mechanistic studies have been suggested that toxic effects of bleomycin are generally attributed to formation of free radicals, mitochondria damages, oxidative stress and inflammation. For this purpose, we explored the direct exposure of bleomycin and protective effects of the betanin and vanillic acid separately against its possible toxicity in rat lung isolated mitochondria. Various mitochondrial toxicity parameters were evaluated including; succinate dehydrogenases (SDH) activity, reactive oxygen species (ROS) formation, mitochondrial swelling, mitochondrial membrane potential (MMP) collapse, malondialdehyde (MDA) and glutathione disulfide (GSSG) levels.
View Article and Find Full Text PDFToxicol Mech Methods
September 2025
Department of Biotechnology, School of Biosciences and Technology, VIT, Vellore, India.
Tuberculosis, caused by , persists as a significant worldwide health issue, resulting in millions of infections and fatalities each year. Treatment predominantly depends on first-line antibiotics, including Isoniazid (INH) and Rifampicin (RIF). Nevertheless, extended use of these medications is linked to considerable adverse effects, leading to various organ toxicities, especially hepatotoxicity and nephrotoxicity.
View Article and Find Full Text PDFJ Pineal Res
September 2025
School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), School of Tropical Agriculture and Forestry, Hainan University, Sanya, China.
Melatonin, a multifunctional signalling molecule in plants, has been increasingly recognized for its role in improving stress tolerance, regulating hormone signalling, and enhancing crop productivity. Exogenous melatonin application represents a promising strategy to enhance crop productivity under global agricultural challenges. This study aimed to investigate the physiological and molecular mechanisms by which melatonin improves yield in Brassica napus.
View Article and Find Full Text PDFImmunopharmacol Immunotoxicol
September 2025
Neuroscience Research Center, Suleyman Demirel University, Isparta, Türkiye.
Background: Microglia are brain resident cells that control neural network maintenance, damage healing, and brain development. Microglia undergo apoptosis, cytokine production, and reactive free radicals of oxygen (ROS) in response to lipopolysaccharide (LPS) stimulation. TRPM2 is activated by LPS-induced oxidative stress, but it is inhibited by carvacrol (CARV) and N-(p-amylcinnamoyl)anthranilic acid (ACA).
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