Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Cognitive frailty in elders has become very common in Thailand society and is extremely difficult to manage in clinical practice due to poor detection and diagnosis. Plasma proteomic studies may be able to provide promising protein markers specific to this condition in order to improve the quality of life in the elderly. The purpose of this study was to differentiate and identify a potential protein marker of cognitive frailty in plasma samples by proteomic approaches. Nine plasma samples from elders with cognitive frailty or non-frailty were pooled and subjected to 2D gel separation. Conventional analysis was performed with the stained gel, and the selected protein spot was identified by liquid chromatography-tandem mass spectrometry coupled to a SCIEX TripleTOF 6600+. It was found that fibrinogen gamma (FGG) chain protein was suggested. FGG was further validated with a commercial ELISA kit using both pooled and individual plasma samples. It was found that both pooled and individual samples showed a significant reduction in FGG levels in elders with cognitive frailty. The results from this study suggest that FGG chain may be a potentially useful plasma biomarker for early detection, diagnosis, and therapeutic applications of cognitive frailty in elders in order to achieve sustainable health in an aging society.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387196 | PMC |
| http://dx.doi.org/10.3390/life15081330 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Associated Factors of Cognitive Frailty in People Living with HIV Aged 50 and Older: A Cross-Sectional Study.
Infect Dis Ther
September 2025
Department of Nursing, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, China.
Introduction: Cognitive frailty (CF), which typically precedes dementia and functional decline, serves as a more robust predictor of adverse health outcomes compared to physical frailty alone, representing a critical challenge in promoting healthy aging among older people living with HIV (PLWH) aged ≥ 50 years. This study aimed to investigate the prevalence of cognitive frailty and identify its associated factors among PLWH aged ≥ 50 years.
Methods: A convenience sample of 344 PLWH ≥ 50 years was recruited from a tertiary Grade A hospital in Zunyi, China.
Managing diabetes in older adults requires balancing long-term glycaemic control with the prevention of hypoglycaemia, to which this population is particularly vulnerable owing to frailty, multimorbidity and cognitive decline. Guidelines recommend individualized glucose targets for older adults, particularly those with multimorbidity or increased hypoglycaemia risk. For individuals with frailty or cognitive impairment, relaxed HbA1c targets are often appropriate to reduce the risk of adverse events.
View Article and Find Full Text PDFExtreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport.
Immun Ageing
September 2025
Department of Biomedical Data Sciences, Molecular Epidemiology, LUMC, Leiden, The Netherlands.
The MetaboHealth score is an indicator of physiological frailty in middle aged and older individuals. The aim of the current study was to explore which molecular pathways co-vary with the MetaboHealth score. Using a Luminex cytokine assay and liquid chromatography-mass spectrometry-based proteomics we explored the plasma proteins associating with the difference in 100 extreme scoring individuals selected from two large population cohorts, the Leiden Longevity Study (LLS) and the Rotterdam Study (RS), and discordant monozygotic twin pairs from the Netherlands Twin Register (NTR).
View Article and Find Full Text PDFAssociations of frailty and its changes with the risks of depressive symptoms: A multi-cohort study.
Arch Gerontol Geriatr
August 2025
Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, China. Electronic address:
Background: Frailty is a dynamic condition that may affect mental health. This study aimed to investigate the associations of frailty and its changes with the risks of depressive symptoms across multiple regions in aging populations.
Methods: Data were drawn from five cohort studies in the United States, England, Europe, China, and Mexico.