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Previous research has predominantly focused on the impact of emotions on trust repair, yet has largely neglected how the manner of emotional communication influences this process. Centering on guilt-the emotion most commonly experienced by transgressors following a trust breach-this study examines whether spontaneous versus strategic guilt communication exerts differential effects on trust repair, and explores how the severity of the trust violation moderates this relationship. Study 1 compared the trust repair efficacy of spontaneous and strategic guilt communication. Study 2 tested the moderating role of violation severity. Results from Study 1 indicated that spontaneous guilt communication facilitated significantly greater trust repair than strategic communication. Study 2 further revealed that this advantage emerged only when the trust violation was severe. These findings advance theoretical understanding of guilt as a trust repair strategy and offer practical guidance for nurturing and restoring trust in interpersonal contexts, thereby promoting relational harmony.
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http://dx.doi.org/10.3390/bs15081035 | DOI Listing |
Regen Med
September 2025
Symbiosis Centre for Stem Cell Research (SCSCR), Symbiosis School of Biological Sciences (SSBS), Symbiosis International, Deemed University, Lavale, Pune, India.
Aims: This study aimed to enhance the osteoinductive potential of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) by integrating them into a nano-hydroxyapatite (nHAp)-enriched hydrogel scaffold for bone regeneration applications.
Materials & Methods: EVs were isolated from naïve and osteogenically primed MSCs and characterized for morphology, cargo content, and cytocompatibility. Their uptake and osteoinductive activity were assessed using MC3T3 cells within a 3D interpenetrating network (IPN) hydrogel.
Curr Drug Deliv
August 2025
Department of Pharmaceutics, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune 411018, India.
Introduction: Burn wounds are painful injuries that demand immediate and effective management. Conventional wound care solutions often have limitations, such as discomfort during application or removal and potential damage to healing tissue. Therefore, developing novel wound dressings that support biological processes and promote wound healing is highly beneficial.
View Article and Find Full Text PDFInflamm Bowel Dis
September 2025
Gut Microbes and Health Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
Background: Intestinal cells receive incoming signals from neighboring cells and microbial communities. Upstream signaling pathways transduce these signals to reach transcription factors (TFs) that regulate gene expression. In inflammatory bowel disease (IBD), most single nucleotide polymorphisms (SNPs) are in non-coding genomic regions containing TF binding sites.
View Article and Find Full Text PDFAnn Vasc Surg
September 2025
Faculty of medicine, Cairo university, Cairo, Egypt; Karl-Jaspers-Klinik, Zwishchenahn, Germany.
Objectives: Negative Pressure Wound Therapy (NPWT) is an advanced therapy utilizing sub-atmospheric pressure at the wound site to generate a controlled environment that promotes blood flow and stabilizes the wound area. However, its effectiveness in diminishing surgical site complications remains unproven effectively. We aim to assess the impact of iNPWT on the reduction of surgical wound complications, mortality rate, and improvement of healing rate following lower limb amputation.
View Article and Find Full Text PDFMod Pathol
September 2025
Department of Medicine, University of Padua, Italy; Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy. Electronic address:
A subset of gastric cancers (GCs) is linked to Epstein-Barr virus (EBV) infection. This study aims to characterize the histopathological and molecular features of EBV-associated GCs (EBVaGCs), focusing on predictive biomarkers and genomic and transcriptomic analysis. A total of 35 primary EBVaGCs were considered.
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