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http://dx.doi.org/10.1016/j.jacc.2025.06.021 | DOI Listing |
Environ Sci Technol
September 2025
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
While the cancer genome is well-studied, the nongenetic exposome of cancer remains elusive, particularly for regionally prevalent cancers with poor prognosis. Here, by employing a combined knowledge- and data-driven strategy, we profile the chemical exposome of plasma from 53 healthy controls, 14 esophagitis and 101 esophageal squamous cell carcinoma (ESCC) patients, and 46 esophageal tissues across 12 Chinese provinces, integrating inorganic, endogenous, and exogenous chemicals. We first show that components of the ESCC chemical exposome mediate the relationship between ESCC-related dietary/lifestyle factors and clinic health status indicators.
View Article and Find Full Text PDFCell Mol Biol (Noisy-le-grand)
September 2025
Associate Professor, School of Pharmacy, Desh Bhagat University, Mandi Gobindgarh-Punjab 147301, India.
Alcoholic fatty liver disease (AFLD) is a leading cause of chronic liver disease worldwide, contributing to significant morbidity and mortality. Despite its growing prevalence, no FDA-approved pharmacological treatments exist, leaving lifestyle modifications as the primary intervention. AFLD pathogenesis involves a complex interplay of lipid accumulation, oxidative stress, insulin resistance, and inflammation, highlighting the need for innovative therapeutic approaches.
View Article and Find Full Text PDFJ Geriatr Cardiol
August 2025
Department of Quality of Life Sciences, University of Bologna-Alma Mater Studiorum, Bologna, Italy.
Caffeine is a widely consumed stimulant known for its cardiovascular and metabolic effects. However, its impact on cardiovascular risk, including arrhythmias, in older adults remains underexplored. Emerging evidence highlights sex-specific differences in caffeine metabolism, which may influence its role in cardiovascular health.
View Article and Find Full Text PDFInt J Hypertens
August 2025
Department of Internal Medicine, Menelik II Comprehensive Specialized Hospital, Addis Ababa, Ethiopia.
Hypertension or elevated blood pressure is a serious medical condition that significantly increases the risk of diseases of the heart, brain, kidneys, and other organs. Antihypertensive drug adherence is key to controlling blood pressure. This study aimed to assess factors associated with antihypertensive drug adherence and blood pressure control among hypertensive patients in selected public hospitals under the Addis Ababa City Administration.
View Article and Find Full Text PDFAm J Lifestyle Med
September 2025
Center for Behavioral Emergency & Addiction Research, McWilliams School of Biomedical Informatics, the University of Texas Health Science Center at Houston, Houston, TX, USA (ASC, MCT, AL, TCL).
Background: Substance use disorders (SUD) are associated with metabolic dysregulation and nutritional deficiencies. Studies show that incorporating nutrition interventions into treatment may improve physical and psychological health. This study sought to explore dietary and consumer behavior in individuals currently using substances.
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