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Introduction: Morbid obesity (body mass index [BMI] > 40) is associated with complications following total joint arthroplasty (TJA) and often prevents same-day discharge. However, advances in medical optimization are reshaping how patients who have a higher BMI are evaluated. This study examined whether modern preoperative optimization strategies can enable safe TJA for patients who have elevated BMIs at an ambulatory surgery center (ASC) by comparing complication rates (24-hour, one to 90-day) of patients in different BMI classes.
Methods: We retrospectively analyzed 2,367 patients who underwent primary TJA at an academic ASC from January 21, 2021, through September 18, 2024. Patients were categorized into five BMI groups per National Institutes of Health and World Health Organization reference ranges: normal weight (BMI < 25; n = 368), overweight (BMI 25 to < 30; n = 717), obesity class 1 (BMI 30 to < 35; n = 675), obesity class 2 (BMI 35 to < 40; n = 417), and obesity class 3 (BMI ≥ 40; n = 190). Differences in presurgical wait times, intraoperative data, post-anesthesia care unit (PACU) data, and complication rates were analyzed.
Results: There was no significant difference in immediate (24-hour) complications and complications between one and 90 days between BMI groups (P = 0.19 and P = 0.63, respectively). Increasing BMI did not correlate with higher complication rates when controlling for other covariates. Higher BMI was associated with longer presurgical wait times, shorter PACU time, and higher final PACU pain scores before discharge.
Conclusion: This study underscores the importance of personalized medical optimization in enhancing the safety of TJA for patients who have elevated BMIs. Focusing on management of preoperative comorbidities and custom surgical planning can achieve outcomes comparable to those of patients who have normal BMIs at ASCs, questioning BMI as an exclusion criterion and advocating for more inclusive, evidence-based patient selection.
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http://dx.doi.org/10.1016/j.arth.2025.08.065 | DOI Listing |
Int J Surg
September 2025
Department of Gynecology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Background: Ovarian cancer remains the most lethal gynecological cancer, with fewer than 50% of patients surviving more than five years after diagnosis. This study aimed to analyze the global epidemiological trends of ovarian cancer from 1990 to 2021 and also project its prevalence to 2050, providing insights into these evolving patterns and helping health policymakers use healthcare resources more effectively.
Methods: This study comprehensively analyzes the original data related to ovarian cancer from the GBD 2021 database, employing a variety of methods including descriptive analysis, correlation analysis, age-period-cohort (APC) analysis, decomposition analysis, predictive analysis, frontier analysis, and health inequality analysis.
Naunyn Schmiedebergs Arch Pharmacol
September 2025
Dept. of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
The purpose of this study was to investigate the efficacy and safety of add-on metformin treatment in persons with active epilepsy (a-PWE). This is a single-centric, double-blind, placebo-controlled trial randomised a-PWE (1:1) to receive either metformin (extended-release 500 mg) or matching placebo for 6 months along with background antiseizure medications. Primary outcome was percentage change in seizure frequency/month, and secondary outcomes were 50% responder rate, serum mTOR expression, and serum total antioxidant capacity (TAC), body composition analysis, quality of life (QOL), and safety assessment.
View Article and Find Full Text PDFMatern Child Health J
September 2025
University of Southern California, 1845 N Soto St, Los Angeles, CA, 90032, USA.
Objective: To test whether parent restriction, pressure to eat, and maternal concern for child weight mediated the positive association between food insecurity and child body mass index (BMI) in cross-sectional and longitudinal analysis.
Methods: Data were from mother-child pairs (n = 202 at baseline). Children were M = 10.
Phys Eng Sci Med
September 2025
Department of Radiology, Otaru General Hospital, Otaru, Hokkaido, Japan.
In lung CT imaging, motion artifacts caused by cardiac motion and respiration are common. Recently, CLEAR Motion, a deep learning-based reconstruction method that applies motion correction technology, has been developed. This study aims to quantitatively evaluate the clinical usefulness of CLEAR Motion.
View Article and Find Full Text PDFAnn Surg Oncol
September 2025
Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Background: Although several trials have demonstrated the oncologic safety of partial-breast irradiation (PBI) compared with whole-breast irradiation (WBI), data on patient-reported outcomes are mixed. Here we compare breast satisfaction and chest well-being using the BREAST-Q questionnaire among patients undergoing PBI versus WBI.
Patients And Methods: We identified patients undergoing lumpectomy and radiation, and analyzed their BREAST-Q scores preoperatively and postoperatively at 6 months, 1 year, 2 years, and 3 years.