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Article Abstract
Introduction: Nesfatin-1, a peptide coded by the NUCB2 gene, has recently been implicated in the regulation of insulin synthesis and glucose homeostasis. These findings suggest a potential role for nesfatin-1 in the etiology of type 2 diabetes mellitus.
Objective: To analyze the relationship between circulating levels of nesfatin-1 and type 2 diabetes mellitus.
Material And Methods: We used PubMed, Scopus, and DOAJ platforms to search published articles from 2012 to 2024. The keywords used were “diabetes mellitus”, “diabetes”, “type 2 diabetes”, “nesfatin-1”, “NUCB2”, “ELISA”, “plasma”, and “serum”. We included all case-control and cross-sectional studies conducted in humans, with full-text availability, and written in English or Spanish.
Results: We included eight studies comprising 305 patients with type 2 diabetes mellitus and 205 controls. The results showed a significant relationship between nesfatina-1 and type 2 diabetes mellitus with a high heterogeneity index (t2 = 3.91; χ2 = 349.63, p < 0.00001; I2 = 98%).
Conclusions: The results show a significant relationship between nesfatin-1 and type 2 diabetes mellitus, supporting its potential use as a biomarker for this disease
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