Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1148/ryai.250550 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Quantification of Trans- and Cis-Vitamin K1 Isomers in Human Plasma by a Rapid and Sensitive LC-MS/MS Method With Surrogate Matrix.
Biomed Chromatogr
October 2025
Department of Pharmaceutical Analysis, Pharmacy School, Shenyang Pharmaceutical University, Shenyang, China.
A rapid and specific liquid chromatography-tandem mass spectrometry method with a wide linear range was developed and validated for the simultaneous quantification of Vitamin K1 (VK1) trans- and cis- isomers in human plasma. Bovine serum albumin solution (15%) served as a surrogate matrix for preparing the calibrators to establish the quantitative curves. After liquid-liquid extraction, VK1 trans- and cis- isomers in plasma samples were separated on a ChromCore C30 column (15 cm × 4.
View Article and Find Full Text PDFOral pharmacokinetics and tissue distribution of a homogeneous polysaccharide from Auricularia auricula-judae: dual-method validation of absorption and distribution.
Int J Biol Macromol
September 2025
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, 24 Heping Road, Harbin, 150040, PR China. Electronic address:
Polysaccharides encounter significant challenges in vivo pharmacokinetic studies because of their complex structures and the limitations of current detection methods, thereby impeding their development and biomedical applications. This study systematically investigated the oral absorption characteristics and tissue distribution of ME-2, a homogeneous polysaccharide from Auricularia auricula-judae, using a dual-labeling pharmacokinetic approach. First, a fluorescein-5-thiosemicarbazide (FTSC)-based quantitative method was established to analyze plasma pharmacokinetics and tissue concentrations of ME-2, demonstrating robust methodological stability (intra-/inter-day RSD < 15 %) and accuracy (recovery rate 95-103 %).
View Article and Find Full Text PDFQuantitative analysis of coproporphyrin and its precursors as endogenous biomarkers for drug-drug interactions involving OATP1B1 and OATP1B3 in monkeys.
Drug Metab Dispos
August 2025
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. Electronic address:
Coproporphyrin (CP)-I has emerged as a promising endogenous biomarker for investigating organic anion transporting polypeptide (OATP) 1B1/1B3-mediated drug-drug interactions. The precursor eliminated analytical (PEA) method selectively quantifies the endogenous CP-I that should be monitored, whereas the precursor oxidized analytical method quantifies the total CP-I concentration by converting all precursors into CP-I during the sample preparation process. Plasma concentrations of CP-I exhibited a greater magnitude of change in response to rifampicin treatment compared with its precursor in a previous monkey study.
View Article and Find Full Text PDFModel-driven meta-analysis establishes a new consensus view: Inhibitory neurons dominate BOLD-fMRI responses.
Comput Biol Med
September 2025
Department of Biomedical Engineering, Linköping University, Linköping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden; School of Medical Sciences and Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine
Functional magnetic resonance imaging (fMRI) is a pivotal tool for mapping neuronal activity in the brain. Traditionally, the observed hemodynamic changes are assumed to reflect the activity of the most common neuronal type: excitatory neurons. In contrast, recent experiments, using optogenetic techniques, suggest that the fMRI-signal could reflect the activity of inhibitory interneurons.
View Article and Find Full Text PDFOverview of Tools to Evaluate Human Health Toxicity, Ecotoxicity, and Toxicokinetic Profiles in the Hazard Assessment of Chemicals Used in Cosmetics.
Chem Res Toxicol
September 2025
C.F.E.B Sisley Paris, 32 Avenue des Béthunes, 95310 Saint Ouen L'Aumône, France.
The development of alternative methods to animal testing has gained momentum over the years, including the rapid growth of methods, which are faster and more cost-effective. A large number of tools have been published, focusing on Read-Across, (quantitative) Structure-Activity Relationship ((Q)SAR) models, and Physiologically Based Pharmacokinetic (PBPK) models. All of these methods play a crucial role in the risk assessment for cosmetics.
View Article and Find Full Text PDF