Functional Brain Reorganization After Radio Electric Asymmetric Conveyer (REAC) Brain Wave Optimization Gamma (BWO-G) Neuromodulation in Individuals With Chronic Stress Exposure: A Retrospective Case Series With Multimodal Evaluation.

Chronic stress exposure is a widespread and disabling condition that disrupts neurophysiological regulation and affects emotional, cognitive, and somatic domains. In this series, the term "chronic stress exposure" refers to prolonged exposure to psychosocial and occupational stressors that, although not classified as a distinct disorder in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) or International Classification of Diseases, 10th Revision (ICD-10), can induce persistent dysregulation of brain networks involved in emotion and cognition. Radio Electric Asymmetric Conveyer (REAC) Brain Wave Optimization Gamma (BWO-G) is a noninvasive neuromodulation protocol aimed at restoring neural coherence by enhancing subcortical-cortical connectivity. This retrospective case series presents five individuals with exposure to chronic stress who underwent 18 sessions of REAC BWO-G. Pre- and post-treatment evaluations included quantitative electroencephalography (qEEG), Independent Component Analysis (ICA), and standardized low-resolution brain electromagnetic tomography (sLORETA). Across all cases, post-treatment assessments revealed consistent trends of increased power symmetry in delta, theta, and alpha bands, along with frequency shifts and reorganization of dominant cortical activity toward areas associated with emotional regulation and the default mode network. Clinically, all patients reported improvements in emotional stability, sleep quality, and cognitive clarity. These findings support the potential of REAC BWO-G to modulate dysfunctional cortical dynamics associated with chronic stress exposure and highlight the utility of qEEG-based neuroimaging in monitoring therapeutic effects.