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Purpose Of Program: The Kidney Research Scientist Core Education and National Training Program (KRESCENT) was launched in 2005 to enhance kidney research capacity in Canada and foster knowledge translation across the 4 pillars of health research. This program report describes the pan-Canadian KRESCENT 2.0 Health Research Training Platform (HRTP) application process that was awarded a 5-year grant through the pilot Canadian Institutes of Health Research (CIHR) HRTP program, ensuring continuation of this capacity-building program in Canada.
Sources Of Information: Grant application documents including meeting minutes, break out group summaries and recommendations, and Gantt timeline charts. Other resources included websites and journal articles.
Methods: All application-related documents were reviewed. Clarification of process and timelines was provided through interviews with the Nominated Principal Applicant (NPA) Dr R. Todd Alexander, Principal Applicants (PAs) Drs Adeera Levin and Sunny Hartwig, Project Manager (PM) Dr Jenn Klein, members of the Patient Community Advisory Network (PCAN), and the Kidney Foundation of Canada Program (KFoC) Manager Ms. Julie Wysocki via in-person and virtual meetings as well as email correspondence.
Key Findings: The KRESCENT 2.0 HRTP application represents a 6-month pan-Canadian effort spearheaded by the NPA and a pan-Canadian team of PAs spanning multiple jurisdictions, disciplines, and sectors. Early engagement of stakeholders in the Canadian kidney research community, outstanding PM administrative support from the onset of the application process were identified as pivotal for the success of the application. Other essential factors for success included graphic design assistance to effectively communicate key and complex concepts, appointment of an EDI champion, engagement with a diverse group of collaborators, and strategic collaboration with other HRTP grant applicants to navigate the ambiguities of the pilot HRTP call. Indispensable, scrupulous final review of the complete application package was generously provided by Dr Robert Quinn (University of Alberta) prior to final grant submission to CIHR.
Limitations: Unlike other funded HRTP applicants, KRESCENT is an established kidney training platform for a small cohort of trainees. Our results may not generalize well to HRTPs with large group cohorts or newly established HRTPs.
Implications: This program report may provide valuable guidance for other groups seeking to successfully navigate the CIHR HRTP application process.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374036 | PMC |
http://dx.doi.org/10.1177/20543581251364309 | DOI Listing |
Org Lett
September 2025
College of Materials and Chemical Engineering, Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, China Three Gorges University, Yichang, Hubei 443002, P. R. China.
A novel copper-catalyzed radical cross-coupling reaction for the thioesterification of polyfluoroarenes is developed using KS and aldehydes in water. This protocol employs a readily available KS as a sulfur source, eliminating the need for hazardous thiols and organic solvents. The mild reaction conditions are compatible with a wide range of functional groups, providing access to diverse polyfluoroaryl thioesters.
View Article and Find Full Text PDFJAMA Cardiol
September 2025
Department of Medicine, Cardiovascular Medicine, Stanford University, Stanford, California.
Importance: Consumer wearable technologies have wide applications, including some that have US Food and Drug Administration clearance for health-related notifications. While wearable technologies may have premarket testing, validation, and safety evaluation as part of a regulatory authorization process, information on their postmarket use remains limited. The Stanford Center for Digital Health organized 2 pan-stakeholder think tank meetings to develop an organizing concept for empirical research on the postmarket evaluation of consumer-facing wearables.
View Article and Find Full Text PDFCell Tissue Res
September 2025
Grupo de Investigaciones Biológicas y Moleculares (GIByM), Instituto de Química Básica y Aplicada del Nordeste Argentino (IQUIBA NEA), Universidad Nacional del Nordeste (UNNE)-CONICET, Corrientes, Argentina.
Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is a crucial process in both physiological and pathological contexts, including cancer. Phospholipases A (PLAs), enzymes found in snake venoms, have attracted attention due to their potential antiangiogenic properties. In this study, we explored the antiangiogenic effects of PLA isoforms isolated from Bothrops diporus venom using a combination of in vivo and ex vivo models.
View Article and Find Full Text PDFHealth Care Anal
September 2025
Harbin Institute of Technology, Harbin, China.
The US healthcare system is characterized by a persistent deadlock, where high costs, low efficiency, and inequity resist fundamental reform. This stalemate is rooted in deep ideological divides, political polarization, a fragmented fiscal structure, and the power of entrenched interest groups. This article analyzes how recent trade protectionist policies, specifically tariffs on pharmaceuticals and their inputs, intersect with this domestic gridlock.
View Article and Find Full Text PDF