98%
921
2 minutes
20
Objective: To investigate the impact of the restorative emergence angle and splinting configurations on peri-implant soft and hard tissues.
Materials And Methods: Thirty implants were placed in the mandibular premolars (P2, P3, P4) of five beagle dogs. In a split-mouth design, each animal received both narrow (NE) (emergence angle = 30°) and wide (WE) (emergence angle = 60°) abutments on each side of the mandible. The implants were subsequently splinted. Radiographic images were captured at 0, 4, 12, and 24 weeks post-restoration. Biopsy samples were then collected for histomorphometric analysis and circularly polarized light examination. All analyses were performed based on the splinted positions: either the mesial or distal end of the terminal implant, the splinted zone of the terminal implant, or the splinted zone of the middle implant.
Results: Radiographic evaluation showed more pronounced bone remodeling in the WE group. In histomorphometric analysis, both the vertical distance from the implant shoulder to the alveolar bone crest and the infiltrated connective tissue areas were significantly larger in the WE group. Conversely, the NE group exhibited a longer connective tissue attachment. Analysis using circularly polarized light indicated a significantly reduced area fraction of collagen fibers in the peri-implant epithelium of the WE group, as well as in the oral epithelium of the splinted zone.
Conclusion: A wide emergence angle of implant prostheses can compromise connective tissue attachment, hinder the formation of an adequate soft tissue seal, and potentially lead to marked bone remodeling.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1111/clr.70035 | DOI Listing |
ACS Nano
September 2025
Department of Chemical Physics, Key Laboratory of Precision and Intelligent Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.
The coupling between transition metal dichalcogenides (TMDCs) and SrTiO has recently emerged as a fertile platform for discovering interfacial phenomena, where particle interactions, lattice coupling, and dielectric screening give rise to interesting physical effects. These hybrid systems hold significant promise for two-dimensional (2D) electronics, ferroelectric state control, and metastable phase engineering. However, effective modulation of the interfacial electronic structure remains a critical challenge.
View Article and Find Full Text PDFFuture Med Chem
September 2025
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
In this review, the primary aim is to examine non-azole ring systems that have analgesic activity and, where applicable, to establish structure - activity relationships (SARs) with the nine major pathways, prostaglandin synthesis inhibition, opioid receptor modulation, sodium channel blockade, enhancement of serotonin and norepinephrine levels, cannabinoid receptor (CBR) binding, N-methyl-D-aspartate (NMDA) receptor antagonism, transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonism, and P2X purinergic receptor blockade, have been described for pain relief. Analgesic effects have been observed in compounds containing ring systems such as piperidine, piperazine, pyridine, pyridazine, pyrazine, morpholine, thiomorpholine, pyran, thiopyran, indane, benzofuran, benzothiophene, quinoline, quinazoline, and chromene. These ring systems were classified in the whole study, first according to their molecular weights and then by bioisosteric similarity as same as first part.
View Article and Find Full Text PDFClin Investig Arterioscler
September 2025
Department of Clinical Dietetics, Medical University of Lublin, ul. Chodzki 7, 20-059 Lublin, Poland. Electronic address:
Background: Although aggressive low-density lipoprotein cholesterol (LDL-C) reduction has demonstrated significant cardiovascular benefits, concerns have emerged regarding potential adverse effects of very low LDL-C on cellular functions, particularly membrane integrity as cholesterol constitutes an essential component of cellular membranes. The phase angle (PhA), derived from bioelectrical impedance analysis (BIA) reflects cellular membranes integrity and nutritional status. The MALIPID study aimed to assess if LDL-C levels are associated with PhA in high cardiovascular risk patients.
View Article and Find Full Text PDFJ Prosthet Dent
September 2025
Associate Professor, Department of Dental Surgery, Faculty of Dental Surgery, University of Malta, Malta. Electronic address:
A digital workflow merging root submergence, immediate dental implant and definitive intermediate abutment placements, and custom healing abutment fabrication to enhance esthetic and biological outcomes in immediate implant procedures is described. The procedure involves a prosthetically driven plan on intraoral and cone beam computed tomography (CBCT) scans, digital planning using a specialized software program, the creation of a surgical guide, and the digital design of custom components. A 3-dimensionally (3D) printed healing abutment was produced by following specific protocols.
View Article and Find Full Text PDFExp Eye Res
September 2025
School of Basic Medicine, Qingdao University, Qingdao, Shandong Province, 266071, China; Department of Ophthalmology, Qingdao Eighth People's Hospital, Qingdao, Shandong Province, 266121, China; Institute of Stem Cell Regeneration Medicine, School of Basic Medicine, Qingdao University, Qingdao, Shan
Mitochondria play a crucial role in energy production and are intimately associated with ocular function. Mitochondrial dysfunction can trigger oxidative stress and inflammation, adversely affecting key ocular structures such as the lacrimal gland, lens, retina, and trabecular meshwork. This dysfunction may compromise the barrier properties of the trabecular meshwork, impeding aqueous humour outflow, elevating intraocular pressure, and resulting in optic nerve damage and primary open-angle glaucoma.
View Article and Find Full Text PDF