Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
A switchable ring-opening reaction of 3-alkynyl-4-pyrones with CH-active compounds in basic medium has been developed for the efficient synthesis of highly substituted benzofurans and chromones. The best selectivity is achieved under solvent-free conditions for the formation of chromones and in the presence of CuI for the formation of benzofurans. Both conditions are very mild and scalable. A large number of products bearing electron-withdrawing groups have been prepared in good to excellent yields.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.5c02822 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Alkynyl Prins Cyclizations for the Synthesis of Bicyclo[4.3.1] and [3.3.1] Oxygen-Bridged Heterocycles.
J Org Chem
September 2025
Department of Chemistry, University of Rochester, 120 Trustee Road, Rochester, New York 14627, United States.
This report presents the alkynyl -Prins cyclization of Achmatowicz adducts, enabling the synthesis of up to 24 (24) highly functionalized [4.3.1] and [3.
View Article and Find Full Text PDFHalichonine B Inspired Design and Divergent Optimization of Drimanyl Amine for Novel Antimicrobial Leads.
J Agric Food Chem
September 2025
State Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China.
Structurally unique halichonine B is promising for the design of pharmaceutical leads, while function-oriented optimization is unknown in agrochemical science. Our recent practical synthesis offers a great chance for the discovery of antimicrobial leads. "Linker plus replaceable substituents" is exerted, in which up to 9 unique linkers together with diverse substituents from a wide chemical space are investigated for optimization of the readily available drimanyl amine.
View Article and Find Full Text PDFThe presentation of self in the age of ChatGPT.
Front Sociol
August 2025
Laboratory of Anthropology of Contemporary Worlds (LAMC), Faculty of Philosophy and Social Sciences, Institute of Sociology, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Contemporary debates about artificial intelligence (AI) still treat automation as a straightforward substitution of human labor by machines. Drawing on Goffman's dramaturgical sociology, this paper reframes AI in the workplace as rather than automation. We argue that the central-but routinely overlooked-terrain of struggle is symbolic-interactional: workers continuously stage, conceal, and re-negotiate what counts as "real" work and professional competence.
View Article and Find Full Text PDFPalladium-catalyzed dearomative 1,4-hydroamination.
Tetrahedron
August 2024
Roger Adams Laboratory, Department of Chemistry, University of Illinois, Urbana, IL, 61801, USA.
A dearomative 1,4-hydroamination of nonactivated arenes has been developed, using a key arene-arenophile photocycloaddition strategy to disrupt aromaticity. Palladium catalysis with K-Selectride as a hydride source uniquely enables selective reactivity and provides access to a range of substituted 1,4-cyclohexadienes from aromatic starting materials. We demonstrate a few synthetic applications of this scalable procedure by preparing highly-functionalized small molecules in three to four steps from naphthalene.
View Article and Find Full Text PDFCollagen-elastin dermal scaffolds enhance tissue regeneration and reduce scarring in preclinical models.
Mater Today Bio
October 2025
Radboud University Medical Center, Research Institute for Medical Innovation, Department of Medical BioSciences, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands.
Severe scarring is an inevitable consequence of large full-thickness skin wounds, often leading to long-term complications that affect patients' well-being and necessitate extended medical interventions. While autologous split-thickness skin grafts remain the clinical standard for wound treatment, they frequently result in contractures, excessive scarring, and the need for additional corrective procedures. To address these challenges, bioengineered skin substitutes capable of promoting efficient healing while reducing complications are highly desirable.
View Article and Find Full Text PDF