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Hypertension is the greatest risk factor for cardiovascular diseases and significantly contributes to cardiovascular mortality. In Japan, the hypertensive population is estimated at 43 million, with only 27% achieving well-controlled blood pressure (BP). The onset of major cardiovascular events, including stroke, myocardial infarction, heart failure, and aortic dissection, frequently occurs during the early morning hours. Accordingly, for over 20 years, the Japanese Society of Hypertension (JSH) has prioritized the management of early morning hypertension and has emphasized the importance of antihypertensive treatment guided by home BP in its treatment guidelines. However, even among hypertensive patients with multiple medications, control of morning BP remains suboptimal, with fewer than 30% achieving target levels below 130/80 mmHg. To address this serious situation, JSH announced their Declaration for the Eradication of Morning Hypertension in 2025, in conjunction with the release of the Guidelines for the Management of Elevated Blood Pressure and Hypertension 2025. The primary specific measure of the declaration involves the Asakatsu BP Action Plan - the Morning Blood Pressure 130 Campaign - which encourages individuals to monitor their morning blood pressure (BP) in various settings, such as homes, workplaces, and BP kiosks set up in public spaces. Additionally, JSH is promoting a Systematic Review Project to raise awareness of the importance of early morning hypertension management nationally and internationally, and a Data Science Project to examine how digital technology can contribute to the promotion of personalized and anticipation medicine through "digital hypertension" research.
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http://dx.doi.org/10.1038/s41440-025-02330-9 | DOI Listing |
Ann Am Thorac Soc
September 2025
University of Florida, Department of Medicine, Gainesville, Florida, United States;
Background: Pulmonary hypertension (PH) is a systemic illness with increasingly subtle disease manifestations including sleep disruption. Patients with PH are at increased risk for disturbances in circadian biology, although to date there is no data on "morningness" or "eveningness" in pulmonary vascular disease.
Research Questions: Our group studied circadian rhythms in PH patients based upon chronotype analysis, to explore whether there is a link between circadian parameters and physiologic risk-stratifying factors to inform novel treatment strategies in patients with PH?
Study Design And Methods: We serially recruited participants from July 2022 to March 2024, administering in clinic the Munich Chronotype Questionnaire (MCTQ).
Indian J Endocrinol Metab
August 2025
Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Introduction: Ectopic adrenocorticotropic hormone (ACTH)/corticotropin-releasing hormone production by tumours causes 5-10% of Cushing's syndrome cases. We present a 21-patient case series with ectopic Cushing's syndrome (ECS) from a tertiary care institute in India.
Methods: Data were collected retrospectively for patients from 1984 to 2004 and prospectively thereafter till 2019.
Nat Sci Sleep
August 2025
Department of Health Management Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People's Republic of China.
Purpose: Chronotype can be used to describe individual's circadian preference in behavioral and circadian rhythm, representing the preferences for earlier or later sleep times. This study aimed to investigate the association of chronotype with hypertension and metabolic parameters in middle-aged and older adults.
Patients And Methods: A total of 945 participants were recruited from December 2023 to December 2024 at First Affiliated Hospital of University of Science and Technology of China.
Blood Press Monit
October 2025
First Department of Cardiology, School of Medicine, National and Kapodistrian University of Athens, Hippokration General Hospital, Athens, Greece.
Blood Press Monit
October 2025
Department of Cardiology, Faculty of Medicine, Alanya Alaaddin Keykubat University, Alanya, Türkiye.