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Article Abstract
Purpose: We aimed to explore the potential prognostic factors associated with poorer outcomes in pediatric patients presenting with acute-onset ataxia to guide early intervention.
Methods: This single-center retrospective cohort study was conducted at the National Center for Child Health and Development between January 2014 and May 2024. Pediatric patients aged 0-18 years who presented with acute-onset ataxia within 7 days of symptom onset were included, excluding those with pre-diagnosed causes of ataxia. Patients were divided into two groups based on their final diagnosis and prognosis: the benign acute cerebellar ataxia (ACA) group for low-risk patients and the clinically urgent neurological pathology (CUNP) group for high-risk patients. Statistical analyses, including chi-square tests and multivariate logistic regression, were performed to identify prognostic factors.
Results: In total, 59 children were included: 34 in the benign ACA group and 25 in the CUNP group. Univariate analysis showed significant differences in headache, vomiting, tremors or dysmetria, age ≥ 5 years, and symptom persistence beyond 3 days between the two groups. Multivariate analysis indicated that age ≥ 5 years (odds ratio [OR] 22.2, 95 % confidence interval [CI] 1.8-640.2) and symptom persistence over 3 days (OR 8.1, 95 % CI 1.5-68.6) were significantly associated with poorer outcomes.
Conclusion: Pediatric patients aged ≥5 years with symptoms persisting for more than 3 days are more likely to require treatment or develop sequelae. Early diagnostic evaluation is important in such cases to avoid delayed intervention.
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| http://dx.doi.org/10.1016/j.braindev.2025.104428 | DOI Listing |
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