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Article Abstract

Few genetically encoded systems based on aptamer-dye pairs meet all the requirements of bioimaging in terms of brightness, contrast, ., thus necessitating their optimization. Here, we report a new biotin-free fluorogenic ligand that demonstrates increased selectivity for Mango II over other DNA/RNA structures in tube and brightness in complex with genetically encoded aptamer-labeled RNA in live cells compared to the known dye.

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http://dx.doi.org/10.1039/d5ob01004gDOI Listing

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