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Article Abstract
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) offers a potential cure for hematologic malignancies, but post-transplant complications, particularly graft--host disease (GVHD), remain major challenges. Regulatory T cells and interleukin-10 () play key roles in immune regulation. This retrospective study investigated the impact of donor -3279 (rs3761548) and -819 (rs1800871) single-nucleotide polymorphisms (SNPs) on clinical outcomes in 92 allo-HSCT recipients, with emphasis on umbilical cord blood transplantation (UCBT). Among UCBT recipients, non-C/C and non-T/T donor genotypes were associated with significantly worse progression-free and overall survival, as well as a higher incidence of chronic GVHD. Multivariable analyses confirmed the prognostic impact of these SNPs. These findings suggest that donor-derived SNPs in key immune regulatory genes may influence post-transplant immune reconstitution. and genotyping could serve as useful biomarkers to guide donor selection and risk stratification in UCBT settings, potentially improving transplantation outcomes.
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| http://dx.doi.org/10.1080/10428194.2025.2550576 | DOI Listing |
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