98%
921
2 minutes
20
This study evaluated the clinical outcomes of a customized technique for restoring large-diameter root canals using prefabricated glass fiber posts (GFPs). The approach involved strategic modifications to accommodate increased root diameters and improve restoration longevity. A total of 104 crowns [45 e.max lithium disilicate (LidiSi) monolithic, 17 e.max LidiSi layered, 27 zirconia monolithic, and 15 zirconia layered] were cemented on endodontically treated teeth (ETT) with GFPs adapted using this technique. The restorations demonstrated a 97.1% survival rate over 24 months, confirming the method's effectiveness, minimal invasiveness, and suitability for rehabilitating ETT. The high success rate underscores the durability of this personalized restoration approach. While these findings suggest promising long-term potential, further research is needed to fully assess the biomechanical impact of all involved components.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.47162/RJME.66.2.11 | DOI Listing |
BME Front
September 2025
State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
This work aims to construct a functional titanium surface with spontaneous electrical stimulation for immune osteogenesis and antibacteria. A silver-calcium micro-galvanic cell was engineered on the titanium implant surface to spontaneously generate microcurrents for osteoimmunomodulation and bacteria killing, which provides a promising strategy for the design of a multifunctional electroactive titanium implant. Titanium-based implants are usually bioinert, which often leads to inflammation-induced loosening.
View Article and Find Full Text PDFMater Today Bio
October 2025
Leibniz Institute of Polymer Research Dresden, Division Polymer Biomaterials Science, Max Bergmann Center of Biomaterials Dresden, 01069, Dresden, Germany.
Glycosaminoglycan-based biohybrid hydrogels represent a powerful class of cell-instructive materials with proven potential in tissue engineering and regenerative medicine. Their biomedical functionality relies on a nanoscale polymer network that standard microscopy techniques cannot resolve. Here, we introduce an advanced analytical approach that integrates transmission electron microscopy, X-ray scattering, and computer simulations to directly and quantitatively characterize the nanoscale molecular network structure of these hydrogels.
View Article and Find Full Text PDFIntroduction: is a spiral-shaped Gram-negative, enterohepatic bacterium classified as a conditional pathogen (pathogenicity group 2). It is known to cause bacteremia and a variety of other diseases in humans. In particular, has been shown to impair intracellular cholesterol metabolism when interacting with macrophages, leading to foam cell formation.
View Article and Find Full Text PDFRSC Chem Biol
September 2025
Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet 17165 Solna Sweden
Labeling the plasma membrane for advanced imaging remains a significant challenge. For time-lapse live cell imaging, probe internalization and photobleaching are major limitations affecting most membrane-specific dyes. In fixed or permeabilized cells, many membrane probes either lose signal after fixation or fail to remain localized to the plasma membrane.
View Article and Find Full Text PDFJ Exp Pharmacol
September 2025
Department of Translational Medicine, University of Ferrara, Ferrara, Italy.
Purpose: Acute graft-versus-host disease (aGVHD) is a significant cause of death in recipients of allogeneic hematopoietic stem cell transplantation. In this type of graft, the intestine is particularly affected, with the loss of intestinal barrier integrity playing a key role in its onset. In this scenario, the aim of the present research was to evaluate defibrotide, a heparin-like compound, marked for severe veno-occlusive disease, as an innovative therapeutic approach for restoring intestinal barrier integrity using an in vitro model and analyzing aGVHD patients' sera and clinical data.
View Article and Find Full Text PDF