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Introduction: Thyroid ultrasound has emerged as a critical diagnostic modality, attracting substantial research attention. This bibliometric analysis systematically maps the 30-year evolution of thyroid ultrasound research to identify developmental trends, research hotspots, and emerging frontiers.
Methods: English-language articles and reviews (1994-2023) from Web of Science Core Collection were extracted. Bibliometric analysis was performed using VOSviewer and CiteSpace to examine collaborative networks among countries/institutions/authors, reference timeline visualization, and keyword burst detection.
Results: A total of 8,489 documents were included for further analysis. An overall upward trend in research publications was found. China, the United States, and Italy were the productive countries, while the United States, Italy, and South Korea had the greatest influence. The journal Thyroid obtained the highest IF. The keywords with the greatest strength were "disorders", "thyroid volume", and "association guidelines". The timeline view of reference demonstrated that deep learning, ultrasound-based risk stratification systems, and radiofrequency ablation were the latest reference clusters.
Discussion: Three dominant themes emerged: the ultrasound characteristics of thyroid disorders, the application of new techniques, and the assessment of the risk of malignancy of thyroid nodules. Applications of deep learning and the development and improvement of correlation guides such as TIRADS are the present focus of research.
Conclusion: The specific application efficacy and improvement of TI-RADS and the optimization of deep learning algorithms and their clinical applicability will be the focus of subsequent research.
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http://dx.doi.org/10.2174/0115734056396607250811115439 | DOI Listing |
Cureus
August 2025
General Surgery, Saqr Hospital, Emirates Health Services, Ras Al Khaimah, ARE.
Introduction: The widespread utilization of neck ultrasound (US) by family physicians for the investigation of non-specific neck symptoms, as well as by endocrinologists and general surgeons for symptomatic thyroid problems, has led to an increase in the detection of nonpalpable thyroid nodules. This presents challenges and dilemmas regarding the decision to perform fine-needle aspiration cytology (FNAC). The routine use of cytology is often considered unnecessary, costly, and inconvenient for patients.
View Article and Find Full Text PDFBiosens Bioelectron
September 2025
College of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Qianjin Street 2699, Changchun, 130012, China. Electronic address:
Papillary thyroid carcinoma (PTC) is the most prevalent form of thyroid cancer with a high incidence among endocrine malignancies. It tends to metastasize early in lymph nodes and differs markedly from other subtypes in biological behavior, clinical management, and prognosis. Therefore, accurately distinguishing PTC from other pathological subtypes is crucial for guiding diagnosis and treatment decisions.
View Article and Find Full Text PDFVestn Oftalmol
September 2025
National Medical Research Center for Endocrinology, Moscow, Russia.
Objective: This study presents a comparative analysis of outcomes of lateral orbital wall decompression performed using ultrasonic bone removal with standard and modified techniques.
Material And Methods: The study included 78 patients (109 orbits) with exophthalmos without visual impairment (subgroups 1A and 1B) and with optic neuropathy (ON) due to thyroid eye disease (TED) (subgroups 2A and 2B). Lateral wall decompression (LWD) was performed using ultrasonic bone removal with a modified (=58, patient subgroups 1A and 2A) or standard (=51, subgroups 1B and 2B) technique.
Front Endocrinol (Lausanne)
September 2025
Department of Ultrasound, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China.
This research aimed to investigate the preoperative risk factors for lymph node metastasis (LNM) in medullary thyroid carcinoma (MTC) using clinical, pathological, serological, ultrasound, and radiomics characteristics. Additionally, it aimed to explore the diagnostic precision of ultrasound (US) for MTC and LNM. A retrospective analysis of 111 nodules was eligible from 104 patients from January 1, 2000, to December 28, 2024.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Department of Medical Ultrasound, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Background: Given the challenge in preoperative diagnosis of high-volume lymph node metastasis (HVLNM) in clinical practice, we constructed and externally validated a comprehensive predictive model that integrated conventional ultrasound characteristics, contrast-enhanced ultrasound (CEUS) parameters, BRAFmutation, and clinicopathological data for HVLNM in clinically lymph node-negative (cN0) papillary thyroid carcinoma (PTC).
Methods: Totally, 126 clinically lymph node-negative (cN0) PTC patients who underwent subtotal or total thyroidectomy and accompanied with prophylactic cervical lymph node dissection between December 2022 and December 2024 were enrolled in this retrospective study, and an additional 47 cN0 PTC patients included for the external validation cohort. Univariate and multivariate analysis were performed to identify the independent risk factors for HVLNM, and a binary logistic regression equation and relevant nomogram was constructed to predict the risk about HVLNM.