Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The current work focuses on the development and testing of point-of-care (POC) devices-based on a color sensor (CSD) and a fiber-optic spectrometer (FOS)-for healthcare monitoring of biological markers. Agarose-based fluorescent indicator-loaded thin film biosensors (TFBs) were synthesized by co-immobilizing analyte-specific enzymes such as glucose oxidase and urease. This study further evaluates enzyme-immobilized polymer-fluorophore-based thin films for the detection of glucose, urea, and pH in plasma and urine samples. TFB-CSD and TFB-FOS biosensor-coupled devices demonstrated linear detection ranges for glucose (0-40 mM), urea (0-100 mM), and pH (4-9), with rapid response times of 30 s for pH sensing and 2 min for glucose and urea sensing. The sequential results obtained using TFB-CSD were compared with those from TFB-FOS. Both devices were found to accurately detect analytes (expressed as average % recovery): glucose (100.32 % for TFB-FOS and 103.59 % for TFB-CSD), urea (114.30 % for TFB-FOS and 108.49 % for TFB-CSD), and pH (103.49 % for TFB-FOS and 105.21 % for TFB-CSD) in blood and urine samples.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cca.2025.120560 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Brazilin attenuates kidney ischemia-reperfusion injury by regulating inflammation, oxidative stress, and mitochondrial dysfunction.
Histol Histopathol
September 2025
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Brazilin, a natural homoisoflavonoid, is the primary bioactive ingredient derived from the bark and heartwood of L. It has been proven to exhibit multiple biological activities and therapeutic potential in chronic degenerative diseases, fibrotic disorders, inflammatory diseases, and cancers. However, whether it is involved in regulating the pathological process of acute kidney injury (AKI) is not fully understood.
View Article and Find Full Text PDFA Rapid Approach for Assessing Body Fluid Matrix Effects.
J Appl Lab Med
September 2025
Department of Pathology, UC San Diego Health, San Diego, CA, United States.
Background: While clinical laboratories routinely perform automated chemistry assays on approved specimens (e.g., plasma and serum), the FDA has not evaluated the validity of these assays for nonapproved specimens (e.
View Article and Find Full Text PDFIn vivo pharmacokinetic evaluation of Veech ketone monoester and metabolites in rats after IV (bolus and infusion) and oral administration.
Int J Pharm
September 2025
Department of Pharmaceutics, VCU School of Pharmacy, Richmond, VA 23298, USA. Electronic address:
Multiple exogenous supplements to achieve ketosis using the oral route have been developed to elevate blood BHB levels on demand and in a controllable fashion. The focus is now shifting to evaluating these supplements as potential therapeutic agents and developing strategies to not only achieve ketosis but also maintain it. One such strategy is to administer these as a continuous IV infusion.
View Article and Find Full Text PDFSex-Specific Chronic Toxicity of the Hexane Fraction of Moringa oleifera Lam. Leaves in Wistar Rats: A 90-Day Oral Exposure Study.
J Ethnopharmacol
September 2025
Department of Pharmaceutics and Pharmaceutical Technology, Usmanu Danfodiyo University, Sokoto.
Ethnopharmacological Relevance: Moringa oleifera L. is widely used in Traditional Medicine across Africa and Asia for managing inflammation, infections, diabetes, and malnutrition. Although its aqueous and ethanolic extracts have been extensively studied, little is known about the safety of its non-polar (hexane) fraction, which may contain unique bioactive compounds.
View Article and Find Full Text PDFXiaoke Decoction Inhibits COX-2-Mediated LDLr Pathway Dysfunction and Protects Renal Function in Diabetic Nephropathy Rats.
Curr Med Sci
September 2025
Shanghai Medical College of Fudan University, Shanghai, 200032, China.
Objective: Traditional Chinese medicine exhibits positive therapeutic effects as a primary or adjunctive treatment for diabetic nephropathy (DN). This study aimed to evaluate the impact and mechanism of action of Xiaoke decoction (XKD), a traditional Chinese medicine, on renal function in DN rats.
Methods: A rat model of DN was established, and the rats were divided into five groups (n = 7 per group): normal control group (NC), DN model group (DN), low-dose XKD treatment group (DN + XKD-L, 1.