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| http://dx.doi.org/10.1016/j.jaad.2025.08.030 | DOI Listing |
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Background: A plant-focused, healthy dietary pattern, such as the Mediterranean diet enriched with dietary fiber, polyphenols, and polyunsaturated fats, is well known to positively influence the gut microbiota. Conversely, a processed diet high in saturated fats and sugars negatively impacts gut diversity, potentially leading to weight gain, insulin resistance, and chronic, low-grade inflammation. Despite this understanding, the mechanisms by which the Mediterranean diet impacts the gut microbiota and its associated health benefits remain unclear.
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Laboratory of Applied Immunology in Aquaculture, Department of Cell Biology, Embryology and Genetics, Federal University of Santa Catarina, 88035-972 Florianópolis, SC, Brazil. Electronic address:
Environmental and nutritional factors are critical in modulating the immune system of Penaeus vannamei, particularly under viral threats such as white spot syndrome virus (WSSV). This study evaluated the effects of two Amazonian plant-based feed additives, buriti (Mauritia flexuosa) and pracaxi (Pentaclethra macroloba) brans, on shrimp immunocompetence, oxidative balance, and resistance to WSSV. Shrimp were fed diets supplemented with 4% or 8% of each ingredient.
View Article and Find Full Text PDFTranscriptomic analysis of the mechanism of male reproductive injuries caused by the mixture of three phthalates in rats.
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Department of Environmental Hygiene and Toxicology, School of Public Health, Wenzhou Medical University, Wenzhou 325035, China. Electronic address:
Phthalates (PEs) are widespread in environment, and human beings are unavoidably exposing to the mixture of PEs, which may induce male reproductive health risks. In order to investigate the mechanism of male reproductive injuries caused by the mixture of di-2-ethylhexyl phthalate, dibutyl phthalate and butyl benzyl phthalate (MPEs), male rats were orally exposed to 16 mg/kg/d MPEs (L-MPEs) and 450 mg/kg/d MPEs (H-MPEs) for 90 days, and the results showed that MPEs decreased the weights of testes, epididymis and periepididymis fat, decreased serum levels of male hormones, increased abnormal sperm rate, and caused testicular histopathological damages, such as atrophy and cavitation of seminiferous tubules, spermatids exfoliation, Leydig cells hyperplasia and accumulation of lipid droplets in the testicular interstitium. Testicular transcriptomic analysis identified 100 differently expressed genes (DEGs) in L-MPEs group and 10,880 DEGs in H-MPEs group, and these DEGs mainly involved in signaling pathways of focal adhesion, PI3K-Akt, AGE-RAGE, axon guidance, PPAR, MAPK and etc.
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Vancomycin is one of the most commonly used parenteral antibiotics for treating drug-resistant bacterial infections, however, it is hindered by nephrotoxicity. We previously demonstrated that zileuton could delay the onset of vancomycin-associated nephrotoxicity in rats. Here, we sought to understand the mechanism(s) of zileuton renal protection.
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