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Multiplicative adjustment factors to standardize milk, fat, and protein lactation yields for age, parity, season of calving, geographical region, milking frequency, and previous days open were last updated in 1994. Since then, the national animal model has updated age-parity adjustments within each 5-year period, but those were not publicized or summarized until now. New multiplicative adjustment factors were estimated using 101.5 million milk, 100.5 million fat, and 81.2 million protein lactation records from 1960 to 2022 in a multitrait model. The pedigree file included 91.3 million animals of all dairy breeds and crossbreds. Along with breeding values for those, the animal model included 392 unknown parent groups, 39.9 million permanent environmental effects, 1.3 million herd-by-sire interactions, and regressions on pedigree inbreeding and heterosis. New age-parity factors were estimated within each 5-year time period-breed combination, and new season factors were estimated within each time period-climate region combination. Instead of mature equivalent, the new age factors standardize records to second-parity cows calving at 36 mo, which was already the policy in genetic evaluations since 2005, to make averages of standardized records much closer to observed herd averages. Seasonal effects were estimated within 5 new regions defined by the average climate zone scores for each state. Within each region, the seasonal differences in lactation yields are smaller in recent decades, suggesting that improved housing and management is mitigating the effect of the environment. The final adjustment factor is the product of 2 new multiplicative factors for age-parity and season-region and the 2 original factors for previous days open and milking frequency, all combined to produce a single multiplier for adjusting actual yields to get standardized yields. These new factors were designed for application to lactation records in the national database and have been distributed to cooperators who also use standardized records to encourage widespread adoption of a uniform approach to improve management comparisons of yields within herds.
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http://dx.doi.org/10.3168/jds.2025-26275 | DOI Listing |
JAMA Neurol
September 2025
Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
Importance: Exposure to fine particulate matter air pollution (PM2.5) may increase risk for dementia. It is unknown whether this association is mediated by dementia-related neuropathologic change found at autopsy.
View Article and Find Full Text PDFEnviron Toxicol Chem
September 2025
Statistical Ecotoxicology, University of Bayreuth, Bayreuth, Germany.
Several micro- and nanoplastic particle (MNP) traits, like polymer type, size, and shape, have been shown to influence MNP toxicity. However, the direction and strength of these moderating effects are often unclear, and generalizations from single studies are challenging to establish. Meta-analyses increase generalizability and derive more accurate and precise effect size estimates by combining measurements from published studies.
View Article and Find Full Text PDFCancer Epidemiol Biomarkers Prev
September 2025
Brigham and Women's Hospital, Boston, MA, United States.
Background: Colorectal cancer (CRC) risk models routinely adjust for endoscopic screening because of a) possible confounding with other risk factors and b) possible alteration of natural history of the disease due to adenoma detection and removal.
Methods: In this study, we defined a subject as screen-covered (SC) if a colonoscopy was performed in the past 10 years, and not screen-covered (NSC) otherwise. We created CRC risk models separately for SC and NSC subjects (HRSC, HRNSC) and then obtained a screening-coverage adjusted HR estimate (HRfull) based on a weighted average of ln(HRSC) and ln(HRNSC) with weight equal to the proportion of SC person-time in the NHS population.
Cancer Epidemiol Biomarkers Prev
September 2025
National Cancer Institute, Bethesda, MD, United States.
Background: Alcohol consumption is a risk factor for certain cancers and is increasing in the United States. We estimated the impact of alcohol consumption on cancer incidence trends in the United States from 2008-2019 across six alcohol-related cancers among men and women.
Methods: Average daily alcohol consumption (ADC) was calculated from the National Health Interview Survey (NHIS, 1998-2009) and adjusted to per capita sales data to account for underreporting alcohol use.
Indian Pediatr
September 2025
Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Objective: To determine the cyclosporine trough (C) and two-hour post-dose concentrations (C) in children with nephrotic syndrome (NS) and study the factors influencing them.
Methods: In this ambispective cohort study, children with NS (including frequently relapsing, steroid-dependent and steroid-resistant nephrotic syndrome) on cyclosporine therapy were enrolled. Clinical and laboratory data were recorded.