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http://dx.doi.org/10.1097/JS9.0000000000003187 | DOI Listing |
Seizure
August 2025
Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, PE, Brazil.
Background: To systematically evaluate the efficacy, safety, and tolerability of adjunctive lacosamide (LCM) in children and adolescents with drug-resistant epilepsy (DRE).
Methods: A systematic review and single-arm meta-analysis was conducted in accordance with PRISMA 2020 guidelines. MEDLINE, Embase, and Cochrane Library were searched up to April 2025.
Pediatr Int
January 2025
Department of Pediatrics, Hiroshima City Funairi Citizens Hospital, Hiroshima, Japan.
NPJ Genom Med
August 2025
Pharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, China.
Personalized precision dosing remains an unmet clinical need. This study used population pharmacokinetic (PopPK) modeling to evaluate transitioning lacosamide (LCM) in children with epilepsy from body weight (BW)-based (mg/kg) to simplified BW-band or fixed-dose (mg) regimens. Real-world data from 190 patients were analyzed using nonlinear mixed-effects modeling program, comparing a BW-based model (Model I) and a genotype-guided model (Model II); the latter showed superior predictive performance.
View Article and Find Full Text PDFInt J Surg
August 2025
Department of Pediatrics, Puer People's Hospital, Yunan, China.
Food Chem Toxicol
October 2025
Department of Pediatric Neurology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
To investigate the histologic effects of topiramate (TPM), lamotrigine (LTG), levetiracetam (LEV), lacosamide (LCM), clobazam (CLB), and zonisamide (ZNS) on rat bone. Seventy male Wistar-Albino rats (aged 21-24 days) were divided into 7 experimental groups with 10 rats each:(i) Control group, (ii) TPM group (40 mg/kg/day), (iii) LTG group (10 mg/kg/day), (iv) LEV group (200 mg/kg/day), (v) LCM group (30 mg/kg/day), (vi) CLB group (50 mg/kg/day), and (vii) ZNS group (100 mg/kg/day). All the drugs were administered by gavage for 90 days.
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