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Article Abstract
In 2020, Y280-lineage H9N2 low pathogenic avian influenza was detected in South Korea for the first time. Active surveillance from live bird markets (LBMs) and farms revealed the continuous circulation of Y280-lineage H9N2 viruses, replacing the previously indigenous Y439-lineage and becoming dominant in South Korea. Antigenic mapping showed a substantial antigenic difference between the Y280 and Y439-lineage viruses. Bayesian phylodynamic approach suggests the introduction of Y280-lineage viruses from China and revealed the frequent exchange of viruses between LBM and farms. The presence of mammalian adaptation markers and high binding affinity to human-type sialic acid receptor raise a concern on interspecies transmission of the viruses to mammals. These findings underscore the importance of continued genomic surveillance to monitor the evolution of H9N2 viruses and assessment of zoonotic potential.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367370 | PMC |
| http://dx.doi.org/10.1155/tbed/8009335 | DOI Listing |
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