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Pseudomyxoma peritonei(PMP)is rare disease, but in other countries, cytoreductive surgery(CRS)plus hyperthermic intraperitoneal chemotherapy(HIPEC)is the standard treatment, but in Japan it is not covered by insurance and is only being treated at a few institutions. In 2021, Japanese Society of Peritoneal Malignancy issued Clinical Practice Guideline for Peritoneal Malignancy, in which CRS+HIPEC was weakly recommended, but few new centres have started this treatment as it is not covered by insurance. We have been performing CRS+HIPEC for PMP and peritoneal dissemination of colorectal cancer since 1990, and hope to expand this treatment by reporting on our methods and outcomes.
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J Hum Genet
September 2025
Division of Integrative Genomics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Comprehensive genomic profiling (CGP) expands treatment options for solid tumor patients and identifies hereditary cancers. However, in Japan, confirmatory tests have been conducted in only 31.6% of patients with presumed germline pathogenic variants (GPVs) detected through tumor-only testing.
View Article and Find Full Text PDFAnn Gastroenterol Surg
September 2025
Division of Digestive Surgery, Department of Surgery, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan.
Aim: The epidemiology of hemorrhoids is challenging because of variability in sampling methodologies and diagnostic criteria across different studies. This study indirectly clarified the epidemiology of hemorrhoids by investigating the number of invasive treatments for hemorrhoids (ITH) using a nationwide healthcare claims database.
Methods: The annual number and rate of ITH procedures per 100 000 people during 2018-2022 were examined.
Cureus
August 2025
Obstetrics and Gynecology, Yokohama Rosai Hospital, Yokohama, JPN.
Introduction Pelvic organ prolapse (POP) affects up to 30% of women during their lifetime and significantly impairs quality of life. In Japan, laparoscopic sacrocolpopexy was covered by national insurance starting in 2014 and has become an established treatment option. Objective This study evaluates the long-term outcomes of POP surgery, including recurrence and complications, seven years after the introduction of sacrocolpopexy at our institution.
View Article and Find Full Text PDFJ Hum Genet
September 2025
Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan.
In standard short-read whole-exome sequencing (WES), capture probes are typically designed to target the protein-coding regions (CDS), and regions outside the exons-except for adjacent intronic sequences-are rarely sequenced. Although the majority of known pathogenic variants reside within the CDS as nonsynonymous variants, some disease-causing variants are located in regions that are difficult to detect by WES alone, such as deep intronic variants and structural variants, often requiring whole-genome sequencing (WGS) for detection. Moreover, WES has limitations in reliably identifying pathogenic variants within mitochondrial DNA or repetitive regions.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Population Health Sciences, University of Utah, Salt Lake City, Utah, United States of America.
While the COVID-19 pandemic has significantly impacted mental health, limited information exists on the relationship between COVID-19 infection and mental health disorders in children and adolescents. This study explored the association between COVID-19 infection, infection severity, and the risk of depression and anxiety among school-aged youth. Data from the 2019-2021 Utah All Payers Claims Database (APCD) was used to identify children and adolescents (aged 6-15 years in 2019) covered by private insurance or Medicaid.
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