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Article Abstract
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396246 | PMC |
| http://dx.doi.org/10.1016/j.ebiom.2025.105890 | DOI Listing |
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[From the emergence of mpox in the Democratic Republic of the Congo to global health emergencies].
Med Sci (Paris)
September 2025
UMI233 TransVIHMI (Recherches translationnelles sur le VIH et les maladies infectieuses), Université de Montpellier, IRD, INSERM Unité 1175, Montpellier, France.
For a long time neglected, the mpox virus has caused two public health emergency declarations by the World Health Organization in just two years. Rapid detection and characterization of the viral strains involved are crucial for better control of the disease. Recent work on viral genome sequencing in the Democratic Republic of the Congo (DRC) has shown the emergence in 2023 of clade Ib, with sustained human-to-human transmission and rapid spread to several other non-endemic neighboring countries, as well as outside Africa.
View Article and Find Full Text PDFA Dual-Target Real-time PCR for proactive detection of Mpox variants.
J Virol Methods
September 2025
British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:
In 2022, cases of Monkeypox virus (MPXV) in California contained a mutation in the TNF receptor gene (GR2G) that rendered the virus undetectable using a widely adopted public health diagnostic qPCR assay. This underscored the need for a dual-target PCR approach and prompted validation of a second target by the BCCDC Public Health Laboratory. In addition to the GR2G target validated in the original qPCR assay (and duplexed with the endogenous target human β-globin (HBG)), GP113 (OPG128) was identified and validated using both clinical samples and MPXV DNA controls.
View Article and Find Full Text PDFGenomic epidemiology of clade Ia monkeypox viruses circulating in the Central African Republic in 2022-24: a retrospective cross-sectional study.
Lancet Microbe
September 2025
Institut Pasteur de Bangui, Bangui, Central African Republic; Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon. Electronic address:
Background: The spread of monkeypox virus (Orthopoxvirus monkeypox) clade Ib from the Democratic Republic of the Congo to neighbouring countries has raised global concerns, leading to WHO declaring mpox a public health emergency on Aug 14, 2024. We applied genomic epidemiology to investigate the causes of recurrent mpox outbreaks in the Central African Republic. We aimed to determine whether frequent zoonotic spillovers or increased human-to-human transmissions are driving mpox epidemiology.
View Article and Find Full Text PDFVaccination strategies to achieve outbreak control for MPXV Clade I with a one-time mass campaign in sub-Saharan Africa: A scenario-based modelling study.
PLoS Med
September 2025
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Background: Limited mpox vaccination coverage, declining cross-protection from historical smallpox vaccination campaigns, and persistent zoonotic reservoirs leave many sub-Saharan countries susceptible to mpox outbreaks. With millions of vaccine doses made available to the region since late 2024 and the absence of country-specific guidelines for allocation, estimating the country-specific impact of one-time mass vaccination strategies is necessary for ongoing outbreaks and other countries at future risk.
Methods And Findings: We adapted a next generation matrix model to project disease transmission potential for 47 sub-Saharan countries from 2025 to 2050 under four transmission scenarios with different contributions of community versus sexual contacts.
Partial deletion of the OPG164 (A36R) transmembrane phosphoprotein in monkeypox virus clade Ib/sh2023 disrupts the active region involving Tyr140.
Lancet Microbe
August 2025
Department of Microbiology and Immunology, Canadian Center for Vaccinology (CCfV), Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4H7, Canada; Laboratory of Immunity, Shantou University Medical College, Guangdong, China; BioForge Canada Limited, Halifax, NS, Canada. Electronic address: d