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http://dx.doi.org/10.1001/jamaophthalmol.2025.2767 | DOI Listing |
Neurology
October 2025
Norcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, WA.
Background And Objectives: Neuroimaging findings in immune effector cell-associated neurotoxicity syndrome (ICANS) have not been systematically described. We created the chimeric antigen receptor (CAR) T-cell Neurotoxicity Imaging Virtual Archive Library (CARNIVAL), a centralized imaging database for children and young adults receiving CAR T-cell therapy. Objectives of this study were to (1) characterize neuroimaging findings associated with ICANS and (2) determine whether specific ICANS-related neuroimaging findings are associated with individual neurologic symptoms.
View Article and Find Full Text PDFVestn Oftalmol
September 2025
Krasnov Research Institute of Eye Diseases, Moscow, Russia.
Primary open-angle glaucoma (POAG) is characterized by chronic progressive damage to the retinal ganglion cell layer (GCL) and their axons, leading to gradual visual function loss. Currently, the gold standards for structural and functional assessment of the retina in glaucoma are static automated perimetry (SAP) and optical coherence tomography (OCT). However, in clinical practice, data from SAP and OCT may be insufficient to reliably determine the stage of glaucomatous optic neuropathy, monitor its progression, or differentiate it from other causes of visual dysfunction.
View Article and Find Full Text PDFHealth Expect
October 2025
Department of Clinical Psychology and Psychological Therapies, Norwich Medical School, University of East Anglia, Norwich, UK.
Background: During recovery from an acquired brain injury (ABI), social isolation is a common experience that can lead to adverse outcomes. Although social connection is known to play a critical role in alleviating these effects, the ways in which ABI survivors experience and prioritise connection and isolation are not well understood. This review aims to understand how these concepts are perceived, identify the valued outcomes, and examine the social contexts that shape these experiences.
View Article and Find Full Text PDFPalliat Med Rep
June 2025
Department of Oncology, McMaster University, Hamilton, Ontario, Canada.
Background: Community Access to Palliative Care via Interprofessional Teams Improvement (CAPACITI) is a virtual educational program designed to support primary care providers in delivering a palliative approach to care. This study evaluated whether expert-facilitated sessions result in greater self-rated competency than a self-directed format across three CAPACITI modules: Identification and Assessment, Communication, and Ongoing Management.
Methods: We conducted a randomized controlled trial where 566 interprofessional primary care team members were randomized to facilitated or self-directed delivery of the CAPACITI program.
The human mind constructs and updates models of events during comprehension. Event models are multidimensional, multi-timescale, and structured. They enable prediction, shape memory formation, and facilitate action control.
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