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http://dx.doi.org/10.1093/eurheartj/ehaf498 | DOI Listing |
Neurochem Res
September 2025
International Translational Neuroscience Research Institute, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
The concept of the central nervous system (CNS) reserve emerged from the mismatch often observed between the extent of brain pathology and its clinical manifestations. The cognitive reserve reflects an "active" capacity, driven by the plasticity of CNS cellular components and shaped by experience, learning, and memory processes that increase resilience. We propose that neuroglial cells are central to defining this resilience and cognitive reserve.
View Article and Find Full Text PDFBioscience
September 2025
School of Life Sciences, University of Nottingham, Nottingham, England, United Kingdom.
Turtles are renowned for their extreme longevity and tremendous range in body size. Theoretically, large, long-lived organisms should face higher cancer risks because of increased cell numbers and lifetime cellular turnover, yet cancer appears to be exceptionally rare in turtles. In the present article, we synthesize the current knowledge on cancer prevalence in turtles, drawing from zoo necropsies, pathology reports, and comparative oncology studies, and present new data spanning additional species that reinforce this pattern.
View Article and Find Full Text PDFFront Bioeng Biotechnol
August 2025
Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea.
Fast Scan Cyclic Voltammetry (FSCV) is a widely used electrochemical technique to detect rapid extracellular dopamine transients . It employs carbon fiber microelectrodes (CFMEs), but conventional 7 µm diameter CFMEs often suffer from limited mechanical durability and reduced lifespan, hindering their use in chronic monitoring. To improve mechanical robustness and long-term functionality, we fabricated 30 µm diameter CFMEs and modified their geometry via electrochemical etching to form cone-shaped tips.
View Article and Find Full Text PDFEvol Med Public Health
July 2025
Center for Evolution and Medicine, Arizona State University, Life Sciences C, 427 East Tyler Mall, Tempe, AZ 85281, USA.
Background: Reproduction affects health and longevity among females across the life course. While significant focus has been devoted to the role of menarche, menopause remains understudied. Most menopause research is conducted in industrialized populations, where the risk of cardiovascular diseases increases progressively during the menopausal transition.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
August 2025
Laboratory of Molecular Biology, Research Centre for Medical Genetics (RCMG), 115522 Moscow, Russia.
Background: Schizophrenia (SZ) is associated with chronic oxidative stress in the patient's body. Previous studies revealed an increased copy number of genes for 47S pre-ribosomal RNA (pre-rRNA) in SZ patients. In this study, levels of oxidative stress and factors involved in the adaptive response to chronic stress (rDNA transcription) were, for the first time, compared in blood cells of patients with catatonic SZ(C) and paranoid SZ(P), chronic forms of schizophrenia, as well as healthy controls (HC).
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