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Background: Polycaprolactone (PCL) is a synthetic, biocompatible, and biodegradable thermoplastic polyester. Three-dimensionally (3D) printed PCL meshes have demonstrated the ability to conform to the defect morphology, providing stable space maintenance and promoting angiogenesis during hard tissue healing. While PCL has shown promise across various medical applications, clinical studies evaluating its effectiveness for hard tissue augmentation in implant dentistry remain limited.
Methods: This case study included three patients with four implants placed simultaneously with lateral bone augmentation using thermally shaped and trimmed PCL mesh and autogenous bone graft. Cone-beam computed tomography scans were obtained preoperatively, immediately post-augmentation, and at 1-year follow-up. Voxel-based registration was used to standardize measurements, evaluating bone width changes at the implant shoulder level, and 1, 3, 5, and 7 mm apical to the implant shoulder.
Results: At 1 year, all implants remained clinically stable with no adverse events or significant crestal bone loss. Bone width increased at all measured levels post-augmentation. Mean bone gain reached 2.13 mm (1.74-2.70 mm) at 1 mm apical and 1.59 mm (0.78-2.33 mm) at 3 mm apical to the implant shoulder. Final buccal bone thickness exceeded 2 mm in 62.5% of sites (5 out of 8) at the implant shoulder level and 1 mm apical to the implant shoulder.
Conclusions: PCL mesh demonstrated clinical feasibility for simultaneous bone augmentation during implant placement. However, further clinical trials with extended follow-up periods are needed to validate these findings and fully explore the potential of PCL mesh in implant dentistry.
Key Points: Polycaprolactone (PCL) mesh provides a stable, resorbable scaffold for buccal bone augmentation during simultaneous implant placement, offering a minimally invasive alternative to autogenous bone block harvesting. Consistent horizontal bone gain was achieved, particularly near the implant shoulder, with 62.5% of sites exhibiting buccal bone thickness greater than 2 mm at or near the implant shoulder, supporting its clinical effectiveness.
Plain Language Summary: This case study looked at three patients who had areas in their jaws where the bone was too thin or missing to support dental implants. To rebuild the bone, doctors used a special medical material called polycaprolactone (PCL) mesh, a flexible, moldable plastic that can be shaped to fit the bone defect. This mesh was combined with bone graft material to help stimulate new bone growth. Each patient received 3D scans before surgery, right after the procedure, and again 1 year later to monitor progress. In all three cases, the jawbone successfully grew back within 4 months, providing enough support for stable dental implants. The results suggest that PCL mesh can create a healthy space for new bones to grow while keeping the area stable during healing. It also helped reduce surgery time and avoided some of the complications that come with traditional bone graft methods.
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http://dx.doi.org/10.1002/cap.70007 | DOI Listing |
J Mater Chem B
September 2025
Nanostructured Materials Laboratory, University of Georgia, Athens, GA, 30602, USA.
Three-dimensional cell cultures on biomimetic scaffolds have gained significant attention in tissue engineering, drug delivery, and scalable cell production. Current challenges in creating an ideal scaffold are providing maximum space for cells to grow while ensuring efficient nutrient, metabolite, and gas exchange to prevent the formation of necrotic or apoptotic regions. In our work, we grow insulin-producing INS-1 cells on touch-spun polycaprolactone (PCL) fiber scaffolds.
View Article and Find Full Text PDFIndian J Orthop
August 2025
Department of Orthopaedic Surgery, PGIMER, Chandigarh, India.
Background: Biodegradable orthopaedic implants have emerged as an innovative alternative to traditional permanent metallic or inert polymer implants, aiming to provide mechanical support during critical healing phases and subsequently degrade in vivo. Their primary advantage lies in eliminating the need for a second surgery to remove hardware, thus potentially reducing patient morbidity and healthcare costs. Despite these benefits, challenges related to unpredictable degradation kinetics, mechanical strength, and biocompatibility have restricted their widespread clinical application.
View Article and Find Full Text PDFClin Adv Periodontics
August 2025
Division of Periodontics, Department of Stomatology, Taipei Veterans General Hospital, Taipei, Taiwan.
Background: Polycaprolactone (PCL) is a synthetic, biocompatible, and biodegradable thermoplastic polyester. Three-dimensionally (3D) printed PCL meshes have demonstrated the ability to conform to the defect morphology, providing stable space maintenance and promoting angiogenesis during hard tissue healing. While PCL has shown promise across various medical applications, clinical studies evaluating its effectiveness for hard tissue augmentation in implant dentistry remain limited.
View Article and Find Full Text PDFBiofabrication
August 2025
Sabanci University Nanotechnology Research and Application Center, Istanbul 34956, Turkey.
2D TiCT(MXene) is attracting significant attention in tissue engineering. The incorporation of these promising materials into conventional scaffolds remains challenging, particularly with physicochemical properties compatible with biological systems. Melt electrowriting (MEW) has emerged as a powerful additive manufacturing technique for biofabrication of customized three-dimensional (3D) scaffolds composed of bioactive materials.
View Article and Find Full Text PDFBiomater Adv
July 2025
Interdisciplinary Research Centre in Biomedical Materials, COMSATS University Islamabad, Lahore Campus, Lahore 54000, Pakistan. Electronic address:
Background: To address traditional/commercial surgical meshes linked complications like fibrosis, seroma, and bacterial infections, this study highlights the benefits of using lightweight, large-pore, all natural material meshes for abdominal wall healing, soft tissue repair and regeneration.
Method: This study presents a first-of-its-kind approach combining hand-knitted silk fibroin (SF) meshes with spin-assisted dip-coated biopolymer-phytochemical composites for soft tissue repair. The multifunctional mesh fabricated via a sustainable crochet method- weft hand-knitted silk fibroin (SF) meshes was surface-functionalized with spin-assisted dip biopolymer-phytochemical coatings.