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Article Abstract
A formal synthesis of product with tetrahydroflurenone structure as selective estrogen receptor modulator has been realized. The Rh-catalyzed [3 + 2 + 1] reaction of yne-vinylcyclopropanes and CO (20 mmol scale, in 87% yield) for building the 6/5/5 skeleton, and a Heck coupling reaction constructing the [3.2.1] framework, are the two key reactions in this 11-step synthesis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362305 | PMC |
| http://dx.doi.org/10.3762/bjoc.21.127 | DOI Listing |
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