Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
What Is Already Known About This Topic?: Carbapenem-resistant (CRKP) poses a major threat to global health. The co-production of multiple carbapenemases has emerged as a critical concern, further limiting the effectiveness of last-resort antibiotics such as ceftazidime-avibactam.
What Is Added By This Report?: This study identifies an IncP6 plasmid co-harboring both and in a clinical isolate of . Comprehensive genomic analysis reveals a complex plasmid structure shaped by recombination events and highlights its potential for mobilization, underscoring the heightened risk of carbapenem resistance.
What Are The Implications For Public Health Practice?: The emergence and diversification of plasmids co-harboring distinct carbapenemase genes highlight the urgent need for comprehensive genomic surveillance, stringent infection control protocols, and judicious antimicrobial management. These measures are essential to curtail the spread and evolution of multidrug-resistant organisms, which pose a substantial threat to public health globally.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361916 | PMC |
| http://dx.doi.org/10.46234/ccdcw2025.178 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synergistic antimicrobial and antibiofilm effects of plant-active ingredients and antibiotics on multidrug-resistant Acinetobacter baumannii.
J Appl Microbiol
September 2025
Sivas Cumhuriyet University, Faculty of Medicine, Department of Medical Microbiology, 58140 Sivas, Türkiye.
Aims: The increasing antimicrobial resistance, particularly in Acinetobacter baumannii, complicates the treatment of infections, leading to higher morbidity, mortality, and economic costs. Herein, we aimed to determine the in vitro antimicrobial, synergistic, and antibiofilm activities of colistin (COL), meropenem, and ciprofloxacin antibiotics, and curcumin, punicalagin, geraniol (GER), and linalool (LIN) plant-active ingredients alone and in combination against 31 multidrug-resistant (MDR) A. baumannii clinical isolates.
View Article and Find Full Text PDFAnti-plasmid defense in hypervirulent involves Type I-like and Type IV restriction modification systems.
Emerg Microbes Infect
September 2025
Infectious Diseases Translational Research Programme, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Hypervirulent (hvKp) and classical multidrug-resistant (MDR) strains belong to distinct lineages and hvKp are typically characterized by hypermucoid capsules that have been shown to limit horizontal gene transfer (HGT), including plasmid acquisition. However, the convergence of hypervirulence and MDR is increasingly common worldwide. When we profiled 127 antibiotic-susceptible hvKp strains, we found that most (86%) are highly permissive to plasmid transfer despite their capsules.
View Article and Find Full Text PDFUnmasking Cultural Taboos: Cancer, Graphic Medicine, and Neelam Kumar's .
Perspect Biol Med
September 2025
In the 21st century, cancer remains shrouded in complex ways, imbued with sociocultural meanings that extend far beyond its clinical and biological aspects. The fear and anxiety surrounding cancer often prompt family and friends to respond with either excessive protection or emotional detachment, leaving patients feeling isolated and unsupported. This article challenges entrenched stereotypes, particularly cultural tendencies in India to conceal cancer diagnoses, associate the disease with karmic retribution, and view it through fatalistic and death-centered perspectives.
View Article and Find Full Text PDFPancreatic Islet Transplantation in Extrahepatic Sites: Evaluation of the Venous Sac in Large Mammal Models.
Diabetes Metab J
September 2025
Institute of Medical & Public Health Research, Ilia State University, Tbilisi, Georgia.
Background: The long-term clinical efficacy of intraportal islet transplantation is hampered by islet loss due to inflammation, oxidative stress, and insufficient vascularization. This study explores the venous sac as an alternative implantation site for islet transplantation in large animal models.
Methods: An immunosuppressed, diabetic cynomolgus monkey received allogeneic islet implants in its mesenteric venous sac, with metabolic assessments over 112 days.
Impact of cryoballoon size adjustability on procedural and clinical outcomes.
Europace
September 2025
Department of Cardiovascular Medicine, Institute of Science Tokyo, Tokyo, Japan.