Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: The feasibility of renal multi-delay arterial spin labeling (ASL) imaging at 5 T remains unclear.
Purpose: To evaluate the feasibility of the saturated multi-delay renal ASL (SAMURAI) sequence at 5 T by comparing image quality and perfusion quantification with 3 T.
Study Type: Prospective, cross-sectional.
Population: Twenty healthy volunteers (28.6 ± 7.8 years, 9 males) for primary comparison; 6 volunteers (24.2 ± 1.5 years, 5 males) for reproducibility study at 5 T.
Field Strength/sequence: SAMURAI sequence at 3 T and 5 T.
Assessment: The SAMURAI sequence was optimized at 5 T with renal-specific B1 shimming and an optimized saturation scheme by numerical simulation. Each participant underwent 3 T and 5 T scans in randomized order. Cortical T1 value, renal blood flow (RBF), arterial and tissue bolus arrival times were measured. The signal-to-noise ratio (SNR) and cortico-medullary contrast-to-noise ratio (CNR) were calculated from perfusion-weighted images. Short-term repeatability (n = 20) and reproducibility (n = 6) tests of quantitative parameters were performed at 5 T.
Statistical Tests: Differences and agreement between 3 T and 5 T were analyzed using the Wilcoxon signed-rank test, intraclass correlation coefficients (ICC) and linear correlation analysis (R). The repeatability at 5 T was assessed by ICC. A p < 0.05 was considered statistically significant.
Results: Renal cortical T1 values were significantly higher at 5 T than 3 T (1417.9 ± 75.7 ms vs. 1184.2 ± 84.4 ms), with R = 0.509. Cortical RBF showed an insignificant difference between 5 T and 3 T: 324.4 (interquartile range [IQR]: 310.1-366.4) vs. 329.7 (IQR: 309.5-368.1) [mL/100 g/min] (p = 0.333), with R = 0.914. 5 T showed significantly higher mean SNR (4.6 vs. 3.9) and CNR (3.2 vs. 2.0) than 3 T across all inversion times, with excellent repeatability and reproducibility of quantitative parameters (ICC = 0.855-0.973).
Data Conclusions: Renal quantitative imaging with SAMURAI sequence at 5 T is feasible and repeatable, with significantly higher SNR and CNR than 3 T and strong interfield agreement of cortical RBF measurements.
Technical Efficacy Stage: 1.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jmri.70079 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Saturated Multi-Delay Renal Arterial Spin Labeling Technique at 5 T MR: A Comparative Study With 3 T.
J Magn Reson Imaging
August 2025
School of Biomedical Engineering, Tsinghua University, Beijing, China.
Background: The feasibility of renal multi-delay arterial spin labeling (ASL) imaging at 5 T remains unclear.
Purpose: To evaluate the feasibility of the saturated multi-delay renal ASL (SAMURAI) sequence at 5 T by comparing image quality and perfusion quantification with 3 T.
Study Type: Prospective, cross-sectional.
SAMURAI: shallow analysis of copy number alterations using a reproducible and integrated bioinformatics pipeline.
Brief Bioinform
November 2024
Department of Biology, University of Padova, Via U.Bassi 58/ B, 35131, Italy.
Shallow whole-genome sequencing (sWGS) offers a cost-effective approach to detect copy number alterations (CNAs). However, there remains a gap for a standardized workflow specifically designed for sWGS analysis. To address this need, in this work we present SAMURAI, a bioinformatics pipeline specifically designed for analyzing CNAs from sWGS data in a standardized and reproducible manner.
View Article and Find Full Text PDFCharacterization of kidneys in patients with systemic sclerosis by multi-parametric magnetic resonance quantitative imaging.
Magn Reson Imaging
June 2024
Center for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, Beijing, China. Electronic address:
Article Synopsis
- - The study aimed to assess how effective multiparametric magnetic resonance (MR) imaging is in examining kidneys in patients with systemic sclerosis (SSc) compared to healthy individuals.
- - In 46 patients with SSc and 22 healthy controls, various MR imaging parameters (like T2*, T1 values, renal blood flow) were significantly different between the groups, indicating kidney function issues in SSc patients, particularly those with the diffuse cutaneous form (dcSSc).
- - The findings suggest that multi-delay ASL perfusion imaging can be a valuable tool for better understanding and classifying kidney conditions in SSc patients, as it highlights differences in kidney function that may not be apparent through traditional methods.
Saturated multi-delay renal arterial spin labeling technique for simultaneous perfusion and T quantification in kidneys.
Magn Reson Med
September 2022
Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China.
Purpose: To propose a free-breathing simultaneous multi-delay arterial spin labeling (ASL) and T mapping technique with a stepwise kinetic model for renal assessment in a single 4-min scan at 3 T.
Methods: The proposed saturated multi-delay renal arterial spin labeling (SAMURAI) sequence used flow-sensitive alternating inversion recovery (FAIR) preparation, followed by acquisition of 9 images with Look-Locker spoiled gradient recalled echo (SPGR). Pre-saturation at the imaging slice was used to achieve saturation-based T mapping.
The complete mitochondrial genome of (Hymenoptera: Scelionidae), the candidate for the biological control of (Hemiptera: Pentatomidae).
Mitochondrial DNA B Resour
July 2021
Department of Life Sciences, University of Siena, Siena, Italy.
The samurai wasp (Ashmead, 1904) is a parasitoid hymenopteran that came into the limelight as the natural enemy of . Here, we present the complete sequence of the mitochondrial genome of the CREATJ laboratory strain, naturally recovered in Italy in 2018. The molecule conforms to the typical model of animal mitochondrial genomes.
View Article and Find Full Text PDF