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Background: Pediatric cervical spine injury (CSI) is associated with substantial morbidity and mortality. The Pediatric Emergency Care Applied Research Network (PECARN) developed a CSI prediction rule for evaluating children after blunt trauma in the emergency department (ED). The objective of this study was to evaluate the performance of the PECARN CSI prediction rule using emergency medical services (EMS) clinician observations.
Methods: We conducted a multicenter prospective observational study of children younger than 18 years with blunt trauma who were transported to one of 18 participating PECARN EDs by EMS. A convenience sample of EMS clinicians completed case report forms regarding CSI risk factors based on their clinical observations. We then evaluated rule performance with 95% confidence intervals (CI) by applying the PECARN prediction rule using the EMS clinical observations with the primary outcome of CSI. We also calculated rates of spinal motion restriction (SMR) had the algorithm been followed for the study population.
Results: Emergency medical services clinicians completed case report forms for 7,721 (57.4%) patients. Using these EMS cohort data, the PECARN CSI prediction rule had a sensitivity of 88.5% (95% CI, 82.9-94.2%), specificity of 63.1% (95% CI, 62.0-64.2%), positive predictive value of 3.7% (95% CI, 3.0-4.4%), and negative predictive value of 99.7% (95% CI, 99.6-99.9%). The proportion of children placed in SMR would have decreased from 41.5% to 37.7%, and longboard use would have decreased from 17.0% to 9.8% had the rule been applied to this cohort.
Conclusion: The PECARN CSI prediction rule based on EMS clinician observations had good accuracy for CSI in children experiencing blunt trauma. Application of the prediction rule to our EMS patient population would have reduced both SMR and longboard use.
Level Of Evidence: Prospective Observational; Level III.
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http://dx.doi.org/10.1097/TA.0000000000004772 | DOI Listing |
Acc Chem Res
September 2025
Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, Ave. Ferrocarril San Rafael Atlixco 186, Col. Leyes de Reforma 1A sección, Alcaldía Iztapalapa, 09310 Mexico City, Mexico.
ConspectusWhat does the word antioxidant mean? Antioxidants are supposed to be nontoxic, versatile molecules capable of counteracting the damaging effects of oxidative stress (OS). Thus, when evaluating a candidate molecule as an antioxidant, several aspects should be considered. Antioxidants are more than free radical scavengers.
View Article and Find Full Text PDFArch Dis Child
September 2025
Department of General Pediatrics, Erasmus MC Sophia, Rotterdam, The Netherlands.
Objective: To externally validate the Paediatric Emergency Care Applied Research Network (PECARN) rule for identifying febrile infants aged <60 days at low risk of serious bacterial infections (SBIs) and assess the utility of the rule with C reactive protein (CRP) instead of procalcitonin (PCT).
Methods: Secondary analysis of data from the Management and Outcomes of Fever in Children in Europe (MOFICHE) study (12 paediatric emergency departments in eight European countries, January 2017 to April 2018) and a Swedish study (four paediatric emergency departments, January 2014 to December 2020). Previously healthy febrile infants aged ≤60 days were included.
Eur J Vasc Endovasc Surg
September 2025
Department of Epidemiology, Maastricht University, Maastricht, the Netherlands. Electronic address:
Objective: The current selection of patients for carotid revascularisation is mainly based on neurological symptoms and the degree of carotid artery stenosis. Individualised MRI based PRediction scOre using plaque Vulnerability for symptomatic carotid artEry disease patients (IMPROVE) can identify high risk patients who may benefit from carotid revascularisation, based on intraplaque haemorrhage, stenosis severity, cerebral symptoms, sex, and age. For use in clinical trials and eventual practice, the decision rule must be acceptable to clinicians.
View Article and Find Full Text PDFJAMA Cardiol
September 2025
Department of Cardiology, Inselspital University Hospital of Bern, University of Bern, Bern, Switzerland.
Importance: Right anomalous aortic origin of a coronary artery (R-AAOCA) is a rare congenital condition increasingly diagnosed with the growing use of cardiac imaging. Due to dynamic compression of the anomalous vessel, invasive fractional flow reserve (FFR) during a dobutamine-atropine volume challenge (FFR-dobutamine) is considered the reference standard. A reliable alternative method is needed to reduce extensive invasive testing, but it remains uncertain whether noninvasive imaging can accurately assess the hemodynamic relevance of R-AAOCA.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Objective: This study aimed to investigate comorbidity patterns and potential pathogenic mechanisms in patients with Hashimoto's thyroiditis (HT).
Methods: Patients with HT who visited the outpatient clinic of the Thyroid Department at Dongzhimen Hospital, Beijing University of Chinese Medicine, between June 2021 and December 2024 were included. Association rule analysis and logistic regression analysis were performed using SPSS 25.