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Background: Oral rehydration salt (ORS) solution has been instrumental in substantially reducing diarrhoea-related mortality, particularly in resource-constrained settings such as Bangladesh. However, the full effectiveness of ORS is often undermined by inadequate preparation, improper storage and incorrect administration. We aimed to evaluate mothers' knowledge, attitude and practice regarding ORS preparation and administration for children suffering from diarrhoea in this study.
Methods: The study was carried out at Dhaka Hospital, ICDDR,B, using a qualitative research approach. Based on data saturation, in-depth interviews were conducted with 31 mothers of children under 5 who sought care at the hospital between February and April 2024. The transcribed data were analysed using qualitative content analysis to describe and analyse data.
Results: Although the majority of the mothers had a positive attitude regarding ORS preparation and administration, they lacked proper knowledge on several points, which hampered correct practices. Ten mothers did not know the correct amount of sachet powder to use, while nine mothers lacked the proper knowledge regarding the right amount of water to prepare ORS, which was rather alarming. Only five mothers recognised that ORS does not transfer to the baby through breast milk. Fourteen mothers provided ORS to their child after each episode of purging while the rest did not. Only 15 mothers adhered to the recommended feeding practices while administering ORS during their child's illness.
Conclusion: This study underscores mothers' need for proper health education regarding the preparation and administration of ORS as well as targeted policies promoting the efficacy of ORS in diarrhoea.
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http://dx.doi.org/10.1136/bmjpo-2025-003577 | DOI Listing |
Biomed Chromatogr
October 2025
Department of Pharmaceutical Analysis, Pharmacy School, Shenyang Pharmaceutical University, Shenyang, China.
A rapid and specific liquid chromatography-tandem mass spectrometry method with a wide linear range was developed and validated for the simultaneous quantification of Vitamin K1 (VK1) trans- and cis- isomers in human plasma. Bovine serum albumin solution (15%) served as a surrogate matrix for preparing the calibrators to establish the quantitative curves. After liquid-liquid extraction, VK1 trans- and cis- isomers in plasma samples were separated on a ChromCore C30 column (15 cm × 4.
View Article and Find Full Text PDFJACC Cardiovasc Interv
September 2025
Division of Vascular Surgery, Department of Surgery, the Jikei University School of Medicine, Tokyo, Japan.
Background: Long-term comparative data on drug-eluting stents (DES) and drug-coated balloons (DCB) for femoropopliteal artery (FPA) disease remain limited.
Objectives: The authors sought to compare 3-year outcomes of DES vs DCB without bailout stenting in FPA disease.
Methods: We retrospectively analyzed 1,406 patients from a multicenter registry who underwent endovascular therapy for FPA using DES (n = 342) or DCB (n = 1,064) after the successful lesion preparation.
BMJ Open
September 2025
Department of Gastroenterology, Hepatology, Infectious Diseases and Intoxication, University Hospital Heidelberg, Heidelberg, Germany.
Introduction: Combined vascular endothelial growth factor/programmed death-ligand 1 blockade through atezolizumab/bevacizumab (A/B) is the current standard of care in advanced hepatocellular carcinoma (HCC). A/B substantially improved objective response rates compared with tyrosine kinase inhibitor sorafenib; however, a majority of patients will still not respond to A/B. Strong scientific rationale and emerging clinical data suggest that faecal microbiota transfer (FMT) may improve antitumour immune response on PD-(L)1 blockade.
View Article and Find Full Text PDFJ Affect Disord
September 2025
The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. Electronic address:
Background: Transcranial direct current stimulation (tDCS), a non-invasive brain stimulation method, can improve depressive symptoms by applying weak electric direct currents to the scalp. This study aimed to evaluate the efficacy and safety of adjunctive tDCS for adolescents with first-episode major depressive disorder (FE-MDD).
Methods: This double-blind, randomized, sham-controlled trial (RCT) was conducted between January 3, 2024, and August 24, 2024.
JMIR Med Educ
September 2025
Institute for General Practice and Interprofessional Care, University Hospital Tübingen, Osianderstraße 5, Tübingen, 72076, Germany, 49 70712985285.
Background: The increasing prevalence of dermatological diseases will pose a growing challenge to the health care system and, in particular, to general practitioners (GPs) as the first point of contact for these patients. In many countries, primary care physicians are supported by teledermatology services.
Objective: The aim of this study was to detect learning effects and gains among GPs through teledermatology consultations (TCs) in daily practice.