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Alpha-particle emitters have garnered considerable interest as therapeutic radiopharmaceuticals, with At emerging as a viable candidate. In this study, the activity concentration of an At solution was determined via alpha-particle counting with a liquid scintillation spectrometer. Alpha-particles, in the region of interest set for pulse-height spectral measurement, were counted, and the counts were corrected for alpha-particle counting efficiency determined using Am standard source. The uncertainty in the alpha-particle counting efficiency was the largest contributor to the overall uncertainty. This result suggests that the combined uncertainty can be reduced by improving the method for evaluating alpha-particle counting efficiency.
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http://dx.doi.org/10.1016/j.apradiso.2025.112093 | DOI Listing |
Acta Oncol
September 2025
Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.
Background And Purpose: Photon-counting computed tomography (PCCT) offers enhanced image quality, including improvements in contrast, spatial resolution, and noise reduction. In radiotherapy (RT), optimal image quality is critical for accurate tumor and organ-at-risk delineation. However, reconstruction parameter selection often relies on subjective assessment.
View Article and Find Full Text PDFAppl Radiat Isot
November 2025
National Institute of Advanced Industrial Science and Technology (AIST), National Metrology Institute of Japan, AIST, Tsukuba Central 2, 1-1-1, Umezono, Tsukuba, Ibaraki, Japan.
Alpha-particle emitters have garnered considerable interest as therapeutic radiopharmaceuticals, with At emerging as a viable candidate. In this study, the activity concentration of an At solution was determined via alpha-particle counting with a liquid scintillation spectrometer. Alpha-particles, in the region of interest set for pulse-height spectral measurement, were counted, and the counts were corrected for alpha-particle counting efficiency determined using Am standard source.
View Article and Find Full Text PDFPharmaceutics
July 2025
Vladimir Zelman Center for Neurobiology and Brain Restoration, Skoltech, 3 Nobel Str., Moscow 121205, Russia.
This research focuses on the development of fabrication approaches for microparticles intended for controlled drug delivery. The primary objective is to identify the most suitable polymer type, particle size, and morphology for encapsulating a water-soluble crystalline drug. Optimizing these parameters may enhance structural stability and prolong the release of this active substance.
View Article and Find Full Text PDFPolymers (Basel)
June 2025
Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.
Plywood and particle boards, commonly used in construction and interior environments, are sources of indoor chemical emissions from synthetic adhesives, resins, and surface treatments. Among these, formaldehyde, classified as a group 1 carcinogen by the International Agency for Research on Cancer, and other compounds are associated with oxidative stress, inflammation, and organ toxicity. This study aimed to evaluate the toxicological and physiological effects of plywood and particleboard emissions in female C57BL/6 mice.
View Article and Find Full Text PDFMicrobiology (Reading)
May 2025
Nottingham Digestive Diseases Biomedical Research Centre, Biomolecular Discovery Institute, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK.
Fatty acids have antimicrobial activity against a wide range of bacteria. We therefore aimed to incorporate omega-3 unsaturated -linolenic acid (αLA) into the membrane of antibiotic-loaded liposomes to create a system with dual antibacterial activity against . Liposomes containing 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, cholesterol, sphingomyelin and the far-red fluorescent DiD label, with varying content of αLA (mol% to total lipid), were fabricated using the thin film evaporation method and hydrated with PBS or amoxicillin solution.
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