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Article Abstract
We report the methodology to synthesize nucleic acid dendrons on a solid support via Cu(I)-catalyzed alkyne-azide cycloaddition (CuAAC). Current methods require excess coupling reagents and result in low yields. Our alternative strategy is based on standard solid-phase synthesis followed by 5'-end coupling of a multifunction linker to efficiently afford dendrons. This approach enables the synthesis of DNA/RNA dendrons whose properties are compatible with therapeutic applications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400419 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.5c02877 | DOI Listing |
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