Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Understanding the phase behavior of multicomponent systems is crucial in condensed matter physics, both for practical applications and fundamental exploration. Regardless of chemical composition, topology stands out as a crucial parameter in this context. We studied herein the phase behavior of a 2D catenated network of DNA rings called a kinetoplast in the presence of linear DNA. We examine the system at a fixed kinetoplast DNA concentration and linear DNA size, while varying the concentration of linear DNA. The mixing of circular DNA with linear DNA is reported to lead to the isotropic phase of the mixtures, however, catenated DNA rings (the assembly of circular DNA) lead to the phase separation in the presence of linear DNA. This distinction highlights the profound influence of topology on the phase behavior of polymer blends. The phase-separated aggregates of kinetoplasts exhibit a fractal nature, with the fractal dimension indicating the dominance of the diffusion-limited mechanism in the aggregation process. Although the structure of these aggregates is robust, significant thermal fluctuations in size and shape occur at various length scales. The understanding of the bulk phase behavior of the catenated DNA network provides crucial insights in designing the catenated-linear polymer composites.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d5sm00461f | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Increasing Awareness and Early Detection of Common Skin Diseases in Indonesia Through an mHealth App: Protocol for an Awareness and Acceptability Study and Randomized Controlled Trial.
JMIR Res Protoc
September 2025
Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Background: Various media are used to enhance public understanding about diseases. While mobile health apps are widely used, there is little proof for using such apps to raise awareness of skin diseases.
Objective: We intend to develop an app, called DEDIKASI-app, to raise awareness of skin diseases, including leprosy.
Pain, Agitation, Delirium, and Iatrogenic Withdrawal Syndrome Management in Children Who Are Critically Ill: Protocol for a European Clinical Practice Guideline Using the Grading of Recommendations Assessment, Development, and Evaluation Approach.
JMIR Res Protoc
September 2025
Institute of Higher Education and Research in Healthcare, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Background: In pediatric intensive care units, pain, sedation, delirium, and iatrogenic withdrawal syndrome (IWS) must be managed as interrelated conditions. Although clinical practice guidelines (CPGs) exist, new evidence needs to be incorporated, gaps in recommendations addressed, and recommendations adapted to the European context.
Objective: This protocol describes the development of the first patient- and family-informed European guideline for managing pain, sedation, delirium, and IWS by the European Society of Paediatric and Neonatal Intensive Care.
rev-Gelatin: A Gelatin with Reverse Thermo-Responsive Behavior Inspired by Candy and Ice Cubes Phase Dynamics.
Macromol Biosci
September 2025
Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Conventional gelatin's gel-to-sol transition upon heating restricts its utility in biomedical applications that benefit from a gel state at physiological temperatures such as Pluronic F127 and poly(NIPAAm). Herein, we present "rev-Gelatin", a gelatin engineered with reverse thermo-responsive properties that undergoes a sol-to-gel transition as temperature rises from ambient to body temperature. Inspired by the phase dynamics of common materials like candy and ice cubes, whose surfaces soften or partially melt under warming, facilitating inter-object adhesion- rev-Gelatin leverages this concept to achieve fluidity at room temperature for easy injectability.
View Article and Find Full Text PDFAge-related evolution of serum biochemistry and intestinal fatty acid signaling, innate immune response and barrier function in suckling and newly weaned piglets.
J Anim Sci
September 2025
Centre for Veterinary Systems Transformation and Sustainability, Clinical Department for Farm Animals and Food System Science, University of Veterinary Medicine Vienna, Vienna 1210, Austria.
It is helpful for diagnostic purposes to improve our current knowledge of gut development and serum biochemistry in young piglets. This study investigated serum biochemistry, and gut site-specific patterns of short-chain fatty acids (SCFA) and expression of genes related to barrier function, innate immune response, antioxidative status and sensing of fatty and bile acids in suckling and newly weaned piglets. The experiment consisted of two replicate batches with 10 litters each.
View Article and Find Full Text PDFGonorrhea and Chlamydia Screening for Adolescents and Young Adults in Emergency Departments.
JAMA Pediatr
September 2025
Department of Pediatrics and Emergency Medicine, Children's National Hospital, George Washington University, Washington, DC.
Importance: Adolescents account for almost half of the 2.5 million diagnosed sexually transmitted infections in the US annually, and the emergency department functions as the primary source of health care for many adolescents. No recommendations exist for emergency department gonorrhea and chlamydia screening.
View Article and Find Full Text PDF