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Phenolics are key components for plant survival and have important medicinal uses for human beings. Nevertheless, the approach for identifying all four types of phenolics is still in need by now. In this study, we developed an approach to elucidate all these phenolics, including anthocyanins, flavanols, chlorogenic acid-related compounds and hydroxycinnamate derivatives in plants, taking purple tomato as material. We identified 58 phenolics and addressed their structures. Among them, there were 15 anthocyanins, 30 flavanols, 8 chlorogenic acid-related compounds and 5 hydroxycinnamate derivatives. In tomato, 29 out of 58 phenolics were not reported previously. By quantification, it was found that the total phenolics were more concentrated in the fruit peel, compared to plant leaves and the fruit flesh. Based on these phenolics, we proposed five possible pathways in flavonols, anthocyanins and hydroxycinnamate derivatives. These findings provide new insight into identification and metabolic variation of phenolics in plants.
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http://dx.doi.org/10.1016/j.fochx.2025.102907 | DOI Listing |
ACS Omega
August 2025
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
The development of steroid 5α-reductase inhibitors for the treatment of androgenetic alopecia remains challenging, primarily due to the unavailability of a crystal structure for human steroid 5α-reductase type-1 (SRD5A1) and the adverse effects associated with existing steroidal therapeutic agents such as finasteride and dutasteride. In this study, hydroxycinnamate derivatives were synthesized and evaluated for their inhibitory activity against SRD5A1 using an immortalized human keratinocyte cell-based assay coupled with nonradioactive high-performance thin-layer chromatography analysis. Three ferulate derivatives featuring 2',5'-, 3',4'-, and 3',5'-bis-(trifluoromethyl)-phenyl substituents (, , and ) demonstrated inhibitory activity with half-maximal inhibitory concentrations (IC) of 8.
View Article and Find Full Text PDFMedicina (Kaunas)
August 2025
Mediterranean Institute for Life Sciences, University of Split, 21000 Split, Croatia.
: Alzheimer's disease (AD) is a complex neurodegenerative disorder marked by cholinergic deficits, oxidative stress, amyloid-β (Aβ) aggregation, and tau hyperphosphorylation. Caffeic acid (CA), a naturally occurring hydroxycinnamic acid, has emerged as a promising neuroprotective candidate due to its antioxidant, anti-inflammatory, and enzyme-inhibitory properties. This review systematically evaluates recent in vitro and in vivo evidence regarding the therapeutic potential of CA in AD models and examines the impact of delivery systems and derivatives on its efficacy and bioavailability.
View Article and Find Full Text PDFJ Basic Microbiol
August 2025
Department of Agricultural Microbiology, Tamil Nadu Agricultural University, Coimbatore, India.
Rhizosphere engineering offers a promising strategy to improve crop productivity and soil health by optimizing plant-microbe interactions through targeted modulation of rhizosphere functioning. A key step in this approach is effective recruitment and functional activation of inoculated plant growth-promoting rhizobacteria (PGPR), mainly driven by root exudate-mediated signaling. This study investigates the response of five phylogenetically diversified PGPR strains, Azotobacter chroococcum (Ac1), Azospirillum lipoferum (Az204), Pseudomonas chlororaphis (ZSB15), Bacillus altitudinis (FD48), and Pristia endophytica (NE14) to root exudates derived from three different rice cultivars (BPT5204, Co51, and Co55) at active tillering and panicle initiation stages.
View Article and Find Full Text PDFFood Chem X
August 2025
State Key Laboratory of Vegetable Biobreeding, Sino-Dutch Joint Laboratory of Horticultural Genomics, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Phenolics are key components for plant survival and have important medicinal uses for human beings. Nevertheless, the approach for identifying all four types of phenolics is still in need by now. In this study, we developed an approach to elucidate all these phenolics, including anthocyanins, flavanols, chlorogenic acid-related compounds and hydroxycinnamate derivatives in plants, taking purple tomato as material.
View Article and Find Full Text PDFFitoterapia
August 2025
UMR 7200 Laboratoire d'Innovation Thérapeutique (LIT), CNRS, Strasbourg Drug Discovery and Development Institute (IMS), Université de Strasbourg, 67400 Illkirch-Graffenstaden, France. Electronic address:
The use of plant-based remedies in traditional medecine to combat bacterial infections has been scientifically studied. As part of an ongoing research for the discovery of new therapeutic options to treat bacterial infections, Ammoniacum gum resin from Ferula communis L. roots was explored.
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