Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Assessing parasite population genetic diversity and structure in remote areas is essential for understanding malaria transmission and guiding interventions toward elimination. This study monitored the genetic diversity and population structure of Plasmodium vivax as part of a longitudinal surveillance in Santa Emilia, a hard-to-reach community in Loreto, Peru. A total of 221 of 3,434 P. vivax samples collected through active and passive case detection between 2015 and 2016 were genotyped using 16 neutral microsatellites. Additionally, 139 genotyped samples from 2013, previously reported, were included for comparison. Malaria prevalence (microscopic and submicroscopic), genetic diversity, population differentiation, structure, bottleneck analysis, and relatedness between years were evaluated. We found 56% P. vivax prevalence by quantitative real-time polymerase chain reaction, with 44% submicroscopic infections in 2015 and 2016. Genetic diversity and population differentiation were high between 2013, 2015, and 2016. Parasites from 2015 to 2016 had a lower Jost D. In 2013 and 2015, more than 40% of infections were polyclonal infections, but only 29% were polyclonal infections in 2016. Moderate linkage disequilibrium was found over time. Four populations were detected in 2013, 2015, and 2016, with increasing admixture in 2015-2016. Genetically related parasites with clonal expansion suggest that there was no recent bottleneck. Santa Emilia has a persistent high genetic diversity and structured, temporally differentiated clonal populations over the time periods of the study. This analysis highlights the complexity of parasite dynamics in this remote area of malaria transmission, making it a challenging area for the malaria elimination plan in Peru.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.4269/ajtmh.24-0662 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Morphological Traces of Population Change in the Carpathian Basin (1st-13th Century CE).
Am J Biol Anthropol
September 2025
Magyar Gyula Horticultural, Technical and Vocational Training School, Budapest, Hungary.
Objectives: This study explores cranial morphological variation and population continuity in the Carpathian Basin from the 1st to 13th centuries CE. It focuses on assessing biological differences and similarities across major archaeological periods, with particular emphasis on the Avar, Hungarian Conquest, and Árpádian Age populations.
Materials And Methods: A total of 1,597 adult crania (864 males, 733 females) were analyzed using six neurocranial measurements.
A Novel Mutation of the NOTCH3 Gene in A Young Patient Presenting with an Acute Stroke: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL).
Eur J Case Rep Intern Med
August 2025
National Rehab Hospital, Dublin, Ireland.
Unlabelled: This report provides a detailed analysis of a singular case involving cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in a male patient who suffered a stroke. Our investigation delves into the clinical manifestations, genetic foundations, diagnostic complexities, and prognosis associated with CADASIL. As a notable contributor to stroke occurrence in young patients, CADASIL's impact on morbidity and mortality is influenced by stroke-related complications and cognitive decline.
View Article and Find Full Text PDFGut dysbiosis in cancer immunotherapy: microbiota-mediated resistance and emerging treatments.
Front Immunol
September 2025
Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Cancer is a multifaceted disease driven by a complex interplay of genetic predisposition, environmental factors and lifestyle habits. With the accelerating pace of cancer research, the gut microbiome has emerged as a critical modulator of human health and immunity. Disruption in the gut microbial populations and diversity, known as dysbiosis, has been linked with the development of chronic inflammation, oncogenesis, angiogenesis and metastasis.
View Article and Find Full Text PDFIntegrative profiling of lung cancer biomarkers EGFR, ALK, KRAS, and PD-1 with emphasis on nanomaterials-assisted immunomodulation and targeted therapy.
Front Immunol
September 2025
Department of Thoracic Surgery, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University), Shenzhen, Guangdong, China.
Background: Lung cancer remains the leading cause of cancer-related mortality globally, primarily due to late-stage diagnosis, molecular heterogeneity, and therapy resistance. Key biomarkers such as EGFR, ALK, KRAS, and PD-1 have revolutionized precision oncology; however, comprehensive structural and clinical validation of these targets is crucial to enhance therapeutic efficacy.
Methods: Protein sequences for EGFR, ALK, KRAS, and PD-1 were retrieved from UniProt and modeled using SWISS-MODEL to generate high-confidence 3D structures.
Adult onset cryopyrin-associated periodic syndrome due to germline missense mutation in in a previously healthy middle-aged woman.
Front Immunol
September 2025
Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Background: Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory disease caused by a gain-of-function mutation in the gene, which regulates inflammasome-mediated interleukin-1β (IL-1β) production. This leads to recurrent episodes of fever, rash, and arthritis, typically beginning in childhood.
Objective: To demonstrate the role of a missense mutation, c.