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Purpose: The Peek digital near vision test has been previously validated in a trial setting; here it is assessed in clinic (stage 1) and community (stage 2) settings.
Methods: The study was carried out in the catchment area of Dr. Shroff's Charity Eye Hospital, Mohammadi, Uttar Pradesh, India, with a total of 768 participants. Stage 1 assessed the interobserver variability of Peek near vision impairment (NVI) screening in 168 clinic participants, with three trained community screeners. Stage 2 compared Peek to conventional chart testing for NVI screening using Cohen's kappa coefficient, sensitivity, and specificity and, for quantitative near visual acuity (NVA) measurement, using Bland-Altman limits of agreement (LoA) in 600 participants with two screeners.
Results: In stage 1, interobserver variability using Peek ranged from 96.43% to 98.21% (kappa = 0.92-0.96). In stage 2, there was overall agreement in 95.8% of cases (kappa = 0.91). Peek testing had a sensitivity and specificity of 91.25% (95% confidence interval [CI], 87.22-94.1) and 99.41% (95% CI, 97.86-99.84), respectively. For NVA testing, the 95% LoA between Peek and chart testing were within -0.11 and +0.07 logMAR. Mean test time was 40.3 seconds (95% CI, 38.8-41.7) for Peek versus 46.6 seconds (95% CI, 45.5-47.7) for a conventional chart.
Conclusions: The previously demonstrated validity of Peek testing was maintained when used by trained community screeners.
Translational Relevance: The Peek near vision test can be used as a validated method of NVA/NVI measurement in research, clinical and community settings.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369907 | PMC |
http://dx.doi.org/10.1167/tvst.14.8.24 | DOI Listing |
Br Dent J
September 2025
Professor, Istanbul Medipol University Faculty of Dentistry, Department of Prosthodontics Dentistry, İstanbul, Turkey.
Purpose The aim of this study was to assess the effectiveness of a PEEK (polyether-ether-ketone) ultrasonic tip in the cleaning around implant-supported restorations and to evaluate the effect of different cement types on the amount of residual cement at the restoration margins.Materials and methods A master model with an implant analogue placed in the upper left first premolar region was used to create 72 cast models and zirconia crowns were fabricated for each model. A total of 72 zirconia crowns were divided into two main groups based on the cleaning method applied after cementation.
View Article and Find Full Text PDFBackground: Sotrovimab is a neutralising monoclonal antibody targeting the SARS-CoV-2 spike protein. We aimed to evaluate the efficacy and safety of sotrovimab in the RECOVERY trial, an investigator-initiated, individually randomised, controlled, open-label, adaptive platform trial testing treatments for patients admitted to hospital with COVID-19.
Methods: Patients admitted with COVID-19 pneumonia to 107 UK hospitals were randomly assigned (1:1) to either usual care alone or usual care plus a single 1 g infusion of sotrovimab, using web-based unstratified randomisation.
Bioengineering (Basel)
August 2025
Department of Regulatory Science for Medical Device, Dongguk University, Seoul 04620, Republic of Korea.
This study aimed to assess, using finite element analysis (FEA), the mechanical effects of cortical bone thickness and cancellous bone density on the pull-out strength of suture anchors. A PEEK anchor was modeled and embedded in synthetic bone blocks with cortical thicknesses ranging from 1 to 5 mm and cancellous densities of 10 PCF, 20 PCF, and 30 PCF. Axial tensile loading simulations were conducted for all combinations, and selected cases were validated through experimental pull-out tests using commercial synthetic bone, demonstrating agreement within ±6%.
View Article and Find Full Text PDFDent J (Basel)
August 2025
Faculty of Dentistry, Al-Azhar University, Cairo 11651, Egypt.
The dental industry is continuously developing high-performance polymer (HPP) materials with different qualities for denture frameworks. The aim of this in vitro study was to assess how thermal ageing (TA) affects the flexural strength (FS) and microhardness of two different HPP materials: Nanoksa G-plus and Bio-HPP/PEEK. The TA process was carried out for 5000 cycles at 5 °C and 55 °C in distilled water.
View Article and Find Full Text PDFJ Surg Res
August 2025
Division of General Surgery, Vanderbilt University Medical Center, Section of Colon & Rectal Surgery, Nashville, Tennessee.
Introduction: Approaches for risk stratification in diverticulitis have emphasized lifestyle factors, with a possible emerging role for molecular signatures. We aimed to evaluate whether plasma proteomic profiles complement dietary and genetic factors in diverticulitis risk stratification.
Materials And Methods: This UK Biobank study derived a plasma proteomic risk score for severe diverticulitis (operative or recurrent inpatient disease).