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http://dx.doi.org/10.1001/jamapediatrics.2025.2710 | DOI Listing |
Cureus
July 2025
Department of Ophthalmology, Medical University of Warsaw, Warsaw, POL.
This case study presents a 51-year-old male diagnosed with relentless placoid chorioretinitis (RPC), a rare condition within the spectrum of inflammatory chorioretinopathies, who experienced progressive vision loss following a COVID-19 infection. The patient's clinical presentation was accompanied by a similar episode, misdiagnosed and untreated, nine years earlier. During clinical evaluation, the patient exhibited overlapping features of acute posterior multifocal placoid pigment epitheliopathy (APMPPE), serpiginous choroiditis (SC), and RPC.
View Article and Find Full Text PDFJAMA Pediatr
August 2025
Department of Pediatric Nephrology, Radboud University Medical Center, Amalia Children's Hospital, Nijmegen, the Netherlands.
JAMA Pediatr
August 2025
Département de Pédiatrie, CHU de Limoges, Limoges, France.
JAMA Pediatr
August 2025
Department of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Nephrol Dial Transplant
August 2025
Division of Nephrology, University Health Network, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. The pathogenesis of IgAN is complex, characterized by gut mucosa-kidney interactions which lead to the production of galactose-deficient IgA1 and formation of immune complexes with anti-glycan antibodies. Both arms of the adaptive and innate immune system are implicated in modifying or amplifying inflammatory cascades which lead to disease progression.
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