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Background And Objectives: To evaluate the reliability and clinical applicability of a novel classification system for thoracic posterior longitudinal ligament ossification (OPLL) and its utility in guiding surgical approach selection for anterior controllable ante-displacement fusion (TACAF).
Methods: Based on anatomical and clinical characteristics, thoracic OPLL was classified according to: Grades 1-4 (severity), Zones A-B (location), and Arc morphology (kyphotic curvature). Twenty surgeons independently assessed 50 cases to evaluate system reliability. Fleiss kappa coefficients determined inter- and intra-observer agreement. Clinical validation utilized demographic and perioperative data from 50 patients, including: Neurological function (11-point JOA scale), operative time, blood loss, and major complications.
Results: For grade 3/4 or zone A OPLL, anterior approaches were predominantly preferred. Grade 2 or zone B lesions permitted selective ossification resection. Laminectomy was contraindicated for grade 4 OPLL. Lesions nearer the arc vertex consistently required anterior approaches. All cases managed per recommended protocols demonstrated uniformly excellent JOA score improvement rates across grades/zones, without statistically significant differences.
Conclusion: This novel classification system provides reliable and reproducible standardization for thoracic OPLL, effectively guiding surgical decision-making. Clinical outcomes and complication analyses in 50 patients support its validity for selecting thoracic OPLL decompression methods.
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http://dx.doi.org/10.1007/s00590-025-04489-w | DOI Listing |
Subst Abuse Treat Prev Policy
September 2025
Centre for Interdisciplinary Addiction Research (ZIS), Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Martinistraße 52, 20246, Hamburg, Germany.
Background: Alcohol use disorder (AUD) is conceptualized as a dimensional phenomenon in the DSM-5, but electronic health records (EHRs) rely on binary AUD definitions according to the ICD-10. The present study classifies AUD severity levels using EHR data and tests whether increasing AUD severity levels are linked with increased comorbidity.
Methods: Billing data from two German statutory health insurance companies in Hamburg included n = 21,954 adults diagnosed with alcohol-specific conditions between 2017 and 2021.
BMC Oral Health
September 2025
Oral and Maxillofacial Radiology Department, Cairo university, Cairo, Egypt.
Aim: The purpose of this study was to assess the accuracy of a customized deep learning model based on CNN and U-Net for detecting and segmenting the second mesiobuccal canal (MB2) of maxillary first molar teeth on cone beam computed tomography (CBCT) scans.
Methodology: CBCT scans of 37 patients were imported into 3D slicer software to crop and segment the canals of the mesiobuccal (MB) root of the maxillary first molar. The annotated data were divided into two groups: 80% for training and validation and 20% for testing.
Crit Care
September 2025
Department of Pediatrics I, University Hospital Essen, University of Duisburg-Essen, Hufelandstr, 55, Essen, 45239, Germany.
Background: Gender disparities persist in medical research. This study assessed gender representation trends in first and senior authorships in the five highest-ranked critical care journals (by impact factor) over a 20-year period.
Methods: We analyzed author gender distribution from 2005 to 2024.
Lipids Health Dis
September 2025
Department of Gastroenterology, Weifang People's Hospital, The First Affiliated Hospital of Shandong Second Medical University, 151 Guangwen Street, Weifang, Shandong, 261000, China.
Background: Current scoring systems for hypertriglyceridaemia-induced acute pancreatitis (HTG-AP) severity are few and lack reliability. The present work focused on screening predicting factors for HTG-SAP, then constructing and validating the visualization model of HTG-AP severity by combining relevant metabolic indexes.
Methods: Between January 2020 and December 2024, retrospective clinical information for HTG-AP inpatients from Weifang People's Hospital was examined.
BMC Psychiatry
September 2025
Department of Cognitive Neuroscience, Faculty of Biology, Bielefeld University, Bielefeld, Germany.
Obsessive-compulsive disorder (OCD) is a chronic and disabling condition affecting approximately 3.5% of the global population, with diagnosis on average delayed by 7.1 years or often confounded with other psychiatric disorders.
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