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The number of young athletes who present with combined meniscal and chondral deficiency with the need for joint preservation is increasing. These are challenging situations in which we must balance function with protection of our repair and/or reconstructive techniques but also afford our patients the opportunity to return to sport. Therefore, a careful understanding of mechanical alignment, meniscal repair and reconstructive strategies, and cartilage-restoration techniques is required. Here we present our technique for combined lateral meniscus transplantation with bone block, lateral femoral condyle osteochondral allograft transplantation, and medial closing-wedge distal femur osteotomy using patient-specific instrumentation.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351018 | PMC |
http://dx.doi.org/10.1016/j.eats.2025.103640 | DOI Listing |
Perfusion
September 2025
Department of Surgery, Columbia University, New York, NY, USA.
Static cold storage (SCS) on ice has remained the gold standard preservation method for heart transplantation, and prolonged cold ischemia outside the typical 4-6 hour window is associated with an increased risk of primary graft dysfunction - a consequence attributed to ischemic damage and reperfusion injury. This, unfortunately limits the travel radius for donor heart procurement, a key factor that contributes to the overall shortage of donor organs. Recent research and clinical data have illustrated the validity of other preservation systems in preserving cardiac allografts, and many of these devices have shown promise in potentially prolonging the tolerated ischemic time beyond the accepted standard.
View Article and Find Full Text PDFAm J Transplant
September 2025
Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School; Department of Surgery, Massachusetts General Hospital, Harvard Medical School; Department of Surgery, Hospital of the University of Pennsylvania, Perelman School of Medicine at the University of Pennsylvania
Achieving immune tolerance is a key goal in organ transplantation, as it eliminates the need for long-term immunosuppression. Regulatory B cells (Bregs) present a promising strategy for inducing tolerance. Our previous findings demonstrate that the adoptive transfer of ex vivo-expanded murine splenic B regulatory cells, referred to as TLR-Bregs (TLR9/TLR4 stimulation), induces tolerance to allografts.
View Article and Find Full Text PDFPediatr Transplant
November 2025
Second Department of Internal Medicine, University of Toyama, Toyama, Japan.
JTCVS Open
August 2025
Department of Cardiothoracic Surgery, University of Louisville and Norton Children's Hospital, Louisville, Ky.
Objectives: Severe obesity is an established risk factor for adverse cardiovascular events and heart transplantation (HT) outcomes in adults. However, the effect of severe obesity on children after HT is not well studied. We aimed to examine the prevalence and effect of severe obesity on pediatric HT.
View Article and Find Full Text PDFPlast Reconstr Surg
September 2025
Hansjörg Wyss Department of Plastic Surgery, New York University Langone Health, New York, NY, US.
Background: Facial transplantation offers transformative solutions for patients with severe facial disfigurements. Minimizing ischemia time is critical for preserving tissue viability, and prioritizing facial allograft recovery during multi-organ procurement aims to optimize outcomes. This study evaluates whether prioritizing face allograft procurement affects the outcomes of non-vascularized composite allotransplantation (non-VCA) organ transplants.
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