Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: Frailty is a syndrome characterized by increased vulnerability to stressful events due to diminished metabolic, neuromuscular, and functional reserves. It has been associated with poor outcomes in patients with cardiovascular diseases. This study compares the eyeball test and the Fried test (considered the "gold standard") for frailty assessment in elderly patients in an electrophysiology clinic.
Methods: This prospective study included stable patients aged 75 years and older who were assessed in an electrophysiology clinic. Frailty assessment was conducted using both the Eyeball and Fried tests. Patients were first evaluated by an electrophysiologist who used the Eyeball test to grade frailty on a Fried-type scale (1-5, with frailty defined as a score ≥3). Subsequently, each patient underwent objective measurements of frailty using the Fried test.
Results: A total of 201 patients with a median age of 82 ± 7 years were included in the study, with 62% being males. According to the Fried test, 81 (40%) patients were classified as frail. The majority of frail patients were over 80 years old. The eyeball test demonstrated an 88.9% sensitivity and a 78.3% specificity in diagnosing frailty. Accordingly, positive and negative predictive values were 73.5% and 91.2%, respectively.
Conclusion: The eyeball test is highly accurate for ruling out frailty in elderly outpatients in an electrophysiology clinic. However, when frailty is suspected based on the eyeball test, an additional objective test, such as the Fried test, should be used to confirm the diagnosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000547101 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparison of 10-2 Visual Field Using Melbourne Rapid Fields Online Perimetry and Humphrey Field Analyzer.
Transl Vis Sci Technol
September 2025
Department of Ophthalmology, Kurashiki Medical Center, Kurashiki, Okayama, Japan.
Purpose: Melbourne rapid fields (MRF) online perimetry is web-based software that allows white-on-white threshold perimetry using any computer. This study assesses the perimetric outcomes of MRF10-2 protocol via laptop computer in comparison to Humphrey field analyzer (HFA).
Methods: This prospective and cross-sectional study included 91 eyes from 91 Japanese glaucoma patients.
Perspectives on eye care access and telemedicine-based glaucoma screening among Latine individuals with limited English proficiency.
AJO Int
October 2025
Department of Ophthalmology & Visual Sciences, University of Michigan Medical School, 1000 Wall Street, Ann Arbor, MI, 48105, USA.
Purpose: Michigan Screening and Intervention for Glaucoma and Eye Health through Telemedicine Program (MI-SIGHT) was developed to facilitate access to glaucoma and eye disease screening and improve attendance at recommended follow-up in underserved communities. MI-SIGHT offered free eye disease screenings, low-cost glasses and for those who screened positive for glaucoma, personalized education, and language-concordant coaching grounded in motivational interviewing. The primary aims of this study were 1) To explore barriers to eye care among Latine participants with limited English proficiency (LEP) who screened positive for glaucoma, 2) to understand whether and how the MI-SIGHT program facilitated access to care and 3) to understand participant experience in MI-SIGHT to inform the development of future interventions.
View Article and Find Full Text PDFRetinal progenitor cells (jCell) for retinitis pigmentosa.
Front Cell Neurosci
August 2025
Stem Cell Research Center, University of California, Irvine, Irvine, CA, United States.
Objective: To assess the safety and tolerability of intravitreal injection of human retinal progenitor cells (RPCs) at multiple dose levels in adults with non-syndromic retinitis pigmentosa (RP).
Design: A prospective, multicenter, open-label, single-arm, Phase I/IIa safety study of RPCs in adults with RP ( = 28). Two patient cohorts were studied: Cohort 1: BCVA no better than 20/200 and no worse than Hand Motions, and Cohort 2: BCVA no better than 20/40 and no worse than 20/200).
An in-flight multimodal data collection method for assessing pilot cognitive states and performance in general aviation.
MethodsX
December 2025
Department of Earth and Environmental Science, University of Waterloo, Waterloo, ON, Canada.
Human factors are central to aviation safety, with pilot cognitive states such as workload, stress, and situation awareness playing important roles in flight performance and safety. Although flight simulators are widely used for training and scientific research, they often lack the ecological validity needed to replicate pilot cognitive states from real flights. To address these limitations, a new in-flight data collection methodology for general aviation using a Cessna 172 aircraft, which is one of the most widely used aircraft for pilot training, is presented.
View Article and Find Full Text PDFManipulating Zika virus RNA tertiary structure for developing tissue-specific attenuated vaccines.
EMBO Mol Med
September 2025
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, 100071, Beijing, China.
Traditional live attenuated vaccines (LAVs) are typically developed through serial passaging or genetic engineering to introduce specific mutations or deletions. While viral RNA secondary or tertiary structures have been well-documented for their multiple functions, including binding with specific host proteins, their potential for LAV design remains largely unexplored. Herein, using Zika virus (ZIKV) as a model, we demonstrate that targeted disruption of the primary sequence or tertiary structure of a specific viral RNA element responsible for Musashi-1 (MSI1) binding leads to a tissue-specific attenuation phenotype in multiple animal models.
View Article and Find Full Text PDF