Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Phage therapy for multidrug-resistant Mycobacterium abscessus is constrained by the narrow lytic spectrum of phages due to unknown antiphage mechanisms. Bacteria deploy various defense strategies to prevent phage infection, but few have been comprehensively characterized in mycobacteria. Mycobacteriophage TM4 successfully delivers DNA into M. abscessus but fails to establish infection. Bioinformatic analyses predicted three candidate phage defense systems and multiple individual putative defense proteins in M. abscessus. Among them, Mab_2091, Mab_2092, and Mab_2093, designated CmaABC, are components of a cyclic oligonucleotide-based antiphage signaling system (CBASS) preventing TM4 infection. However, the inability of TM4 to form plaques even in CBASS-deficient M. abscessus implies the involvement of additional resistance mechanisms. Our findings underscore the challenges faced by mycobacteriophages in infecting M. abscessus, and highlight the complex interactions between this pathogen and its viral adversaries.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12359967 | PMC |
| http://dx.doi.org/10.1186/s12866-025-04214-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Outbreak of infections by Mycobacterium abscessus subsp. abscessus associated with cosmetic surgeries in the Brazil/Paraguay border: a binational cohort study, 2021-2022.
Epidemiol Serv Saude
September 2025
Ministério da Saúde, Programa de Treinamento em Epidemiologia Aplicada aos Serviços do SUS, Brasília, DF, Brazil.
Report on a field investigation into the outbreak of skin infections by Mycobacterium abscessus subsp. abscessus following cosmetic procedures. A retrospective cohort study was conducted using secondary data from the Epidemiology Program Applied to SUS Services (EpiSUS) about the investigation conducted in 2022, in partnership with Paraguay's Field Epidemiology Training Program.
View Article and Find Full Text PDFOuabain alleviates -triggered inflammatory responses through dual regulation of NLRP3 inflammasome activity and M1 macrophage polarization.
Front Immunol
September 2025
The Key Laboratory of Shenzhen Respiratory Diseases, Institute of Shenzhen Respiratory Diseases, The First Affiliated Hospital (Shenzhen People's Hospital), School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Introduction: () is a highly drug-resistant pathogen responsible for chronic pulmonary inflammation in humans. The cardiac glycoside ouabain exhibits broad anti-inflammatory effects in various disease models, but its therapeutic potential against -induced pneumonia remains unexplored.
Methods: We investigated the role of ouabain in -induced inflammation using and models.
Functional (re)annotation of proteome using integrative sequence and AI-based structural approaches.
Curr Res Struct Biol
December 2025
Bioinformatics Centre, CSIR-Institute of Microbial Technology (IMTECH), Sector 39A, Chandigarh, 160036, India.
Functional annotation of proteins is crucial in understanding the basic biology of organisms. In the context of pathogens, it can provide valuable insights towards its functional landscape contributing to understanding the molecular mechanisms of pathogenesis and survival. In this study, we explored the applications of sequence and AI-driven structure-based methods to functionally (re)annotate (MAB).
View Article and Find Full Text PDFPrevalence and epidemiologic features of nontuberculous mycobacteria causing persistent surgical site infections in Bangladesh.
IJID Reg
September 2025
Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan.
Objectives: Nontuberculous mycobacteria (NTM) are an increasing cause of extrapulmonary infections affecting skin and soft tissue. This study aimed to determine the involvement of NTM in persistent surgical site infections (SSIs) in Bangladesh.
Methods: Specimens of SSIs (wound swab, pus, sinus discharge) were collected from patients who attended a tertiary care hospital during a 6-month period in 2024.
Culture conversion and macrolide resistance in complex pulmonary disease.
Microbiol Spectr
September 2025
Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, National Clinical Laboratory on Tuberculosis, Beijing Chest Hospital, affiliated Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
Unlabelled: The complex (MABC) is highly resistant to antibiotics, making the pulmonary disease it causes, known as MABC-PD, difficult to treat. Macrolide antibiotics are the main treatment for MABC-PD, but there is ongoing debate about whether to favor azithromycin (AZI) or clarithromycin (CLA). We compared how well AZI and CLA work against MABC and monitored the risk of developing resistance.
View Article and Find Full Text PDF