Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: To evaluate the effects of whole fruit-based products consumption on HbA1c levels in patients with type 2 diabetes mellitus through a systematic review and meta-analysis.
Methods: We searched PubMed, Cochrane Library, and Embase from inception to April 22, 2024, for randomized controlled trials (RCTs) examining the effects of whole fruit-based products consumption on HbA1c in type 2 diabetes mellitus (PROSPERO: CRD42024566638). A random-effects meta-analysis was performed. Mean difference (MD) and 95% confidence intervals (CIs) were calculated; heterogeneity was assessed using I².
Results: Five RCTs involving 245 participants were included. Fruit consumption significantly reduced HbA1c levels (MD, -0.33%; 95% CI, -0.54% to -0.11%; I² = 44%). FBG was also reduced (MD, -6.59 mg/dL; 95% CI, -10.59 to -2.59 mg/dL; I² = 0%), and HDL increased (MD, 2.72 mg/dL; 95% CI, 1.32 to 4.12 mg/dL; I² = 0%). One study had high risk of bias; no serious adverse events were reported.
Conclusions: Whole fruit-based products consumption may improve HbA1c, fasting blood glucose, and HDL cholesterol levels in patients with type 2 diabetes mellitus. REGISTRY AND REGISTRY NUMBER FOR SYSTEMATIC REVIEWS OR META-ANALYSES: PROSPERO number CRD42024566638. The registration date was August 2nd, 2024.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.amjmed.2025.08.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A review of the effect of SGLT2 inhibitors on clinical and glycemic outcomes in hospitalized patients: data from studies that included patients with diabetes.
Hormones (Athens)
September 2025
Division of Endocrinology, Baltimore VA Medical Center, Baltimore, MD, USA.
Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are a fairly new class of agents for diabetes that have demonstrated significant benefits in glycemic control and cardiovascular outcomes with outpatient use. The aim of this review is to provide an overview of the effect of SGLT2i use on glycemic control and clinical outcomes in the hospital setting.An electronic search of PubMed was conducted to analyze publications that assessed the inpatient use of SGLT2i and included patients with diabetes.
View Article and Find Full Text PDFEstimated fracture risk in osteopenic patients with primary hyperparathyroidism.
Endocrine
September 2025
Otorhinolaryngology, Head and Neck Surgery, Candiolo Cancer Institute, FPO-IRCCS Turin, Turin, Italy.
Background: While osteoporosis in primary hyperparathyroidism (PHPT) is widely studied, PHPT patients with osteopenia remain less characterized. This study aimed to evaluate the prevalence, biochemical features, and estimated fracture risk of osteopenic PHPT patients in a real-life cohort.
Methods: We retrospectively analyzed a consecutive series of PHPT patients with available densitometric data at three sites.
Expression of long non-coding RNAs MALAT1, MEG3, and XIST in gestational diabetes mellitus: a cross-sectional study.
Acta Diabetol
September 2025
Department of Endocrinology & Metabolism, Medical College & Hospital, Kolkata, 88, College St. College Square, Kolkata, West Bengal, 700073, India.
Background And Aims: Gestational diabetes mellitus (GDM) is defined as glucose intolerance first identified during pregnancy that does not meet the criteria for overt diabetes. Its pathophysiology shares key features with type 2 diabetes mellitus (T2D), including insulin resistance and inflammation. Emerging evidence suggests that long non-coding RNAs (lncRNAs) are implicated in T2D.
View Article and Find Full Text PDFInfective endocarditis and relationship with diabetes mellitus - Patient characteristics, microbial etiology and mortality.
Infection
September 2025
The Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Inge Lehmanns Vej 7, 16th floor, Copenhagen, 2100, Denmark.
Purpose: Infective endocarditis (IE) has been associated with severe outcomes when complicated by diabetes mellitus (DM). We aimed to report characteristics, microbial etiology, and mortality for patients with IE stratified by DM from a nationwide cohort.
Methods: We used Danish registries, and patients with first-time IE (2010-2020) were stratified by DM.
Augmented glucagon-induced gluconeogenesis in primary hepatocytes from Otsuka Long-Evans Tokushima Fatty rats.
Biosci Biotechnol Biochem
September 2025
Department of Nutrition, Graduate School of Human Life and Ecology, Osaka Metropolitan University, Osaka 558-8585, Japan.
Glucagon dysregulation is a hallmark of type 2 diabetes mellitus (T2DM), yet its early hepatic effects remain unclear. Here, we demonstrate that glucagon-induced gluconeogenesis is markedly enhanced in primary hepatocytes from prediabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a well-established model of human T2DM. Compared to control LETO rats, OLETF hepatocytes showed significantly higher glucagon-stimulated expression of gluconeogenic genes (Pepck, G6pase, Fbp1) at both mRNA and protein levels, along with elevated glucose production.
View Article and Find Full Text PDF