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Spatial suppression is a phenomenon in which, for high-contrast stimuli, larger stimuli typically elicit weaker neural responses and produce worse perceptual performance compared to smaller stimuli. This phenomenon is thought to arise from inhibitory connections between neurons. Although recent studies have suggested that feedback connections from high areas can influence these inhibitory processes, implying that attention may modulate spatial suppression, direct evidence for such modulation remains scarce. In particular, the impact of an important component of attention, alerting, has been overlooked. The present study aimed to explore the effects of two distinct components of attention-alerting and orienting-on spatial suppression. Our results indicate that alerting enhances spatial suppression. Furthermore, upon isolating the influence of orienting after controlling for alerting levels, we discovered that the influence of orienting on spatial suppression is feature-dependent. Specifically, while orienting attention to orientation enhances spatial suppression, orienting to contrast does not elicit the same effect. Our results indicate that spatial suppression is a flexible processing mechanism subject to widespread high-level cognitive modulations.
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http://dx.doi.org/10.1016/j.visres.2025.108676 | DOI Listing |
ACS Electrochem
September 2025
Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom.
The surface structure of an electrocatalyst plays a crucial role in determining the activity. As a model system, gold has been widely investigated as an electro-oxidation catalyst, although there has been much less research on the oxygen evolution reaction (OER) in the potential region of gold oxidation. Here, we combine voltammetric scanning electrochemical cell microscopy (SECCM) and electron backscatter diffraction (EBSD), at different spatial and angular resolutions, respectively, to correlate the local crystallographic structure of polycrystalline goldfocusing on grains close to (113), (011), (114), and (111) orientationswith the electrocatalytic behavior for the OER.
View Article and Find Full Text PDFNatl Sci Rev
September 2025
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China.
Chimeric antigen receptor T (CAR-T)-cell therapy is a promising resolution for solid tumors, but its corresponding clinical translation has been hindered by unsatisfactory therapeutic potency and severe cytokine release syndrome. Herein, tetracycline (Tet)-On inducible human epidermal growth factor receptor 1 (HER1)-targeted CAR-T (Tet-HER1-CAR-T) cells were engineered to enable spatially selective activation at tumor sites by doxycycline (Doxy), which is delivered by pH-responsive stealth liposomal calcium carbonate nanoparticles (Doxy@CaCO-PEG). Compared with the intravenous administration of conventional HER1-CAR-T cells and Tet-HER1-CAR-T cells activated by free Doxy, concurrent intravenous administration of Tet-HER1-CAR-T cells and Doxy@CaCO-PEG leads to the localized tumor activation of Tet-HER1-CAR-T cells and reduced systemic secretion of inflammatory cytokines.
View Article and Find Full Text PDFMed Phys
September 2025
Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Background: Four-dimensional magnetic resonance imaging (4D-MRI) holds great promise for precise abdominal radiotherapy guidance. However, current 4D-MRI methods are limited by an inherent trade-off between spatial and temporal resolutions, resulting in compromised image quality characterized by low spatial resolution and significant motion artifacts, hindering clinical implementation. Despite recent advancements, existing methods inadequately exploit redundant frame information and struggle to restore structural details from highly undersampled acquisitions.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang, Shandong 261053, P.R. China.
Decades of antibiotic misuse have spurred an antimicrobial resistance crisis, creating an urgent demand for alternative treatment options. Although phototherapy has therapeutic potential, the efficacy of the most advanced photosensitizers (PS) is essentially limited by aggregation-induced quenching, which significantly reduces their therapeutic effect. To address these challenges, we developed a cationic metallocovalent organic framework (CRuP-COF) via a solvent-mediated dual-reaction synthesis strategy.
View Article and Find Full Text PDFJ Colloid Interface Sci
August 2025
Research Centre of Ecology & Environment for Coastal Area and Deep Sea, Guangdong University of Technology, Guangzhou 510006, China; Guangdong Basic Research Center of Excellence for Ecological Security and Green Development, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou),
Hypothesis: Gas hydrate formation in sediments is influenced by the availability of gas-water interfacial areas, which governs gas-water interactions. The surface wettability of sediment particles is expected to affect the spatial distribution of water within the pore space, thereby altering the extent of gas-liquid contact. Consequently, by tuning the wettability heterogeneity of the sediment, the spatial distribution of pore water can be regulated, which in turn influences the gas-water interactions and the kinetics of gas hydrate formation.
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