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Marathon terrain significantly impacts athlete performance. This study examined whether level running biomechanics can predict uphill and downhill running economy using a new metric, running grade aptitude (RGA). Forty distance runners (32 males and 8 females) ran on a split-belt treadmill at +4% and -4% gradients, simulating Boston Marathon hills. We assessed stride parameters, foot strike patterns, ground reaction forces, and oxygen consumption during uphill, downhill, and level running. RGA was determined by analyzing the slope of the relationship between oxygen uptake and treadmill grade, categorizing runners as preferring uphill RGA, downhill RGA, or negligible RGA. We found a significant correlation (R2 = .44) between active peak vertical ground reaction forces during level running and downhill running economy (downhill RGA). However, no other variables significantly related to RGA, and no difference in RGA was observed between genders. The study suggests that runners who generate higher peak vertical ground reaction forces during level running are more economical on downhill segments. These findings highlight the importance of individual biomechanical traits in optimizing training and racing strategies for distance runners.
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http://dx.doi.org/10.1123/jab.2024-0212 | DOI Listing |
Light Sci Appl
September 2025
State Key Laboratory of Quantum Optics Technologies and Devices, Institute of Opto-Electronics, Shanxi University, 030006, Taiyuan, China.
The dominant technical noise of a free-running laser practically limits bright squeezed light generation, particularly within the MHz band. To overcome this, we develop a comprehensive theoretical model for nonclassical power stabilization, and propose a novel bright squeezed light generation scheme incorporating hybrid power noise suppression. Our approach integrates broadband passive power stabilization with nonclassical active stabilization, extending the feedback bandwidth to MHz frequencies.
View Article and Find Full Text PDFInt J Sport Nutr Exerc Metab
September 2025
Exercise and Performance Nutrition Laboratory, School of Health Sciences, Lindenwood University, St. Charles, MO, USA.
Caffeine (CAF) mouth rinsing has been considered a practical nutritional strategy among athletes. Recent studies indicate that this nutritional strategy's efficacy may depend on the athlete's prandial state. Therefore, the main aim of the current study is to determine the effect of CAF mouth rinsing on a battery of soccer-specific tests of soccer players in fasted (FST) or fed states (FED).
View Article and Find Full Text PDFeNeuro
September 2025
Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, 43210.
Cancer patients experience circadian rhythm disruptions during and after chemotherapy that can contribute to debilitating side effects. It is unknown how chemotherapy mediates circadian disruptions, and specifically the extent to which these disruptions occur at the level of the principal clock, the suprachiasmatic nuclei (SCN) of the hypothalamus. In the present study, we assessed how the commonly used chemotherapeutic, paclitaxel, impacts the SCN molecular clock and SCN-dependent behavioral adaptations to circadian challenges in female mice.
View Article and Find Full Text PDFDiabetes Obes Metab
September 2025
Graduate School of Physical Education, Myongji University, Yongin, Republic of Korea.
Background: High levels of glycated haemoglobin (HbA1c) in people with type 1 diabetes (T1D) are associated with high mortality and cardiovascular risk. Physical activity is an affordable intervention that is available to most people, but the type and amount of exercise to induce metabolic benefits in T1D are not known with certainty.
Objective: To determine the comparative effectiveness of diverse exercise modes and dosages to influence HbA1c in patients with T1D.
Cureus
August 2025
Medical Education and Simulation, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, GBR.
Introduction: Simulation is a widely used educational tool for both undergraduate and postgraduate medical education. There are different levels of simulation fidelity; low fidelity uses simplistic models but is often cost/time effective, whereas high fidelity tends to bring more realism but is resource-intensive. In undergraduate medical training, simulation is often used for students in their final year of medical school prior to qualifying as a doctor, and therefore, the literature is limited with regard to students in their earlier years of training.
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