Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Microcapsules are considered as one of the most promising drug carriers due to their exceptional characteristics. The cellular uptake of microcapsules is determined by physicochemical properties, yet comprehensive studies on thickness and shape effects are limited. In this study, we developed single-layered poly(amidoamine) (PAMAM) dendrimer microcapsules with tunable thicknesses and morphologies to systematically investigate their cellular internalization. By varying PAMAM generations (G2-G8), the wall thickness can be tuned within the range of 19.3-53.7 nm, while the microcapsule shapes can be determined by the distinct morphologies of the CaCO templates (spherical, peanut-like, dumbbell-like). Cellular uptake studies in DC2.4 cells revealed significant thickness- and shape-dependent trends: among spherical microcapsules, OPC/PAMAM-G6 microcapsules with a thickness of 43.5 nm exhibited higher internalization efficiency than their counterparts, while among OPC/PAMAM-G6 microcapsules, dumbbell-like microcapsules outperformed spherical and peanut-like microcapsules. Notably, dumbbell-shaped microcapsules with negative surface charge (-11.8 mV) demonstrated superior biocompatibility and uptake kinetics. This study demonstrates the structural diversity and functional versatility of PAMAM microcapsules by utilizing oligomeric proanthocyanidins (OPC), proposing a simple and universal method for preparing polyphenol/polymer microcapsules that can be applied to practical drug delivery systems.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/09205063.2025.2543942 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multifunctional Hydrogel Flakes: An Innovative Approach to Localized Delivery of Temozolomide.
ACS Appl Mater Interfaces
September 2025
Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Kraków 30-387, Poland.
The multifunctional systems presented here introduce an innovative and deeply thought-out approach to the more effective and safer use of temozolomide (TMZ) in treating glioma. The developed hydrogel-based flakes were designed to address the issues of local GBL therapy, bacterial neuroinfections, and the bleeding control needed during tumor resection. The materials obtained comprise TMZ and vancomycin (VANC) loaded into cyclodextrin/polymeric capsules and embedded into gelatin/hyaluronic acid/chitosan-based hydrogel films cross-linked with genipin.
View Article and Find Full Text PDFFOXO3 Protects Lens Epithelial Cells From UVB-Induced Oxidative Stress via the AMPK/FOXO3 Signaling Pathway.
FASEB J
September 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Age-related cataract (ARC) represents a major global cause of visual impairment, with ultraviolet B (UVB) radiation recognized as a primary contributor to oxidative damage in the lens. FOXO3, a key regulator of aging, apoptosis, and oxidative stress-induced cell death, was investigated for its role and regulatory mechanisms in UVB-induced oxidative stress using human lens epithelial cells (HLECs). A progressive decrease in FOXO3 protein expression was observed in the lens capsules across various stages of cataract progression, as well as in UVB-exposed animal models and UVB-treated HLECs.
View Article and Find Full Text PDFPharmacokinetic Study and Bioequivalence Evaluation of Two Sustained-Release Tablets of Tamsulosin in Healthy Chinese Subjects Under Fasting and Postprandial Conditions.
Clin Pharmacol Drug Dev
September 2025
Phase I Clinical Research Centre, Wuhan Pulmonary Hospital, Wuhan, China.
Tamsulosin is a highly selective α1A adrenergic receptor antagonist that can relax smooth muscles in the urethra, bladder neck, and prostate and improve urinary disorders. It is therefore widely used to treat lower urinary tract symptoms caused by benign prostatic hyperplasia. The aim of this study is to evaluate the pharmacokinetic (PK) characteristics and bioequivalence of 2 different formulations (tamsulosin sustained-release tablets and tamsulosin sustained-release capsules) in healthy Chinese subjects.
View Article and Find Full Text PDFBile Acid-based Microcapsule-Like Cocrystals of Phytosterols with Enhanced Solubility, Bioavailability, and Bioactivity.
Mol Pharm
September 2025
Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Phytosterols are a class of natural steroids found in various plants. Commercially available phytosterols (PS) are primarily extracted from the deodorized distillate of soybean oil and consist predominantly of β-sitosterol with smaller amounts of stigmasterol and campesterol. Numerous studies have consistently demonstrated the significant lipid-lowering activity of PS.
View Article and Find Full Text PDFEfficacy of Qianlie Shutong Capsule in the Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Single-Centre Retrospective Study.
Arch Esp Urol
August 2025
Department of Urology, The First People's Hospital of Jiujiang, 332000 Jiujiang, Jiangxi, China.
Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent urological condition affecting men's health. This study aims to investigate the clinical efficacy of Qianlie Shutong (QLST) capsule in the treatment of CP/CPPS.
Methods: The medical records of patients with CP/CPPS who were admitted to our hospital from January 2023 to January 2024 were retrospectively analysed.