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Article Abstract
Metformin is one of the most commonly used medications to treat type 2 diabetes. In addition to lowering blood sugar, it can also promote the regeneration of certain organs or tissues. Planarian , with its remarkable regenerative capacity, has become an important model organism for studying pharmacology and regenerative medicine. Planarian eyespot regeneration involves precise tissue regeneration via mechanisms like cell proliferation, differentiation, and gene regulation following body damage. Experiments on planarian eyespot regeneration have confirmed that 1 mM metformin significantly promotes regeneration. Through analysis of the regenerating planarian miRNA database and the metformin-treated transcriptome database, combined with target gene prediction by TargetScan, the axis was finally determined as the research focus. qPCR showed that metformin significantly affects the expression levels of and . was identified as the target gene of through dual luciferase reporter gene analysis. Functional experiments revealed that metformin regulates the expression of via , thereby influencing the regeneration of planarian eyespots. In situ hybridization showed that both and are expressed throughout the entire body. This study reveals the molecular mechanism of metformin regulating planarian regeneration through miRNA, providing further insights into its role in the field of regeneration.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12345652 | PMC |
| http://dx.doi.org/10.3390/ijms26157092 | DOI Listing |
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