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Phytosterols, encompassing plant sterols and stanols, are bioactive compounds prevalent in plant-derived foods. These compounds have garnered attention for their extensive pharmacological properties, which include cardioprotective, anticancer, neuroprotective, hepatoprotective, wound healing, antidiabetic, antimicrobial, immunomodulatory, and anti-aging effects, as well as potential applications in managing ocular diseases and hormonal disturbances. Recent studies indicate that phytosterols may significantly reduce lipid profiles, thereby mitigating cardiovascular disease risk. Furthermore, their role in cancer prevention is underscored by evidence suggesting a significant reduction in cancer risk associated with phytosterol-rich diets. This review aims to gather the current literature on the therapeutic potential of phytosterols for human health, highlighting their diverse biological activities. Overall, this comprehensive overview seeks to elucidate the promising role of phytosterols in enhancing health outcomes and their viability as therapeutic agents.
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http://dx.doi.org/10.1002/cbdv.202500983 | DOI Listing |
Sci Adv
September 2025
Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA.
Sterols are essential isoprenoid derivatives that contribute to membrane structure and function. In plants, they also serve as precursors to phytohormones and specialized metabolites important for development, defense, and health. Although the sterol biosynthetic pathway is considered well-characterized, we report the discovery of a plant-specific cytochrome -like protein, CB5LP, as a critical component of phytosterol biosynthesis.
View Article and Find Full Text PDFPlant J
September 2025
Plant Physiology, Matthias Schleiden Institute for Genetics, Bioinformatics and Molecular Botany, Friedrich Schiller University Jena, 07743, Jena, Germany.
Progestogens and androgens are steroids found in a wide range of plants, but little is known about their physiological functions. In this study, we sowed seeds of angiosperms on progestogen- and androgen-containing medium and analysed their morphological effects. We further investigated the effects of progesterone and testosterone on brassinosteroid profiles and gene expression in A.
View Article and Find Full Text PDFMol Pharm
September 2025
Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Phytosterols are a class of natural steroids found in various plants. Commercially available phytosterols (PS) are primarily extracted from the deodorized distillate of soybean oil and consist predominantly of β-sitosterol with smaller amounts of stigmasterol and campesterol. Numerous studies have consistently demonstrated the significant lipid-lowering activity of PS.
View Article and Find Full Text PDFCell Mol Biol (Noisy-le-grand)
September 2025
IQRAA Centre for Research and Development, IQRAA International Hospital and Research Centre, Kozhikode, Kerala, India.
Terminalia arjuna, an important medicinal plant in traditional Indian systems, has been extensively studied for its cardioprotective bark. However, limited attention has been given to its fruit, which contains several biologically active phytochemicals with potential antioxidant, anti-inflammatory, and immunomodulatory properties. This study aimed to isolate and partially purify phytoactive compounds from the fruit of T.
View Article and Find Full Text PDFNan Fang Yi Ke Da Xue Xue Bao
August 2025
Department of Pathogenic Biology & Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medicine and Life Sciences, Hainan Medical University. Haikou 571199, China.
Objectives: To elucidate the anti-aging effect of β-sitosterol (BS), an important component in the fruits of Miq., in and its regulatory effect on ETS-5 gene to modulate ferroptosis.
Methods: treated with 10 µg/mL BS were monitored for survival time and changes in body length, motility, and reproductive function.